SCHEMBL29866515

SCHEMBL29866515

[2H]C1([2H])c2nn(C)nc2-c2cccc(N)c2N1C

nearest known ligand 0.31

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
MAPT P10636 1/20 0.31
TYK2 P29597 1/20 0.30
MAPK13 O15264 1/20 0.30
EIF2AK2 P19525 1/20 0.30
MAPK12 P53778 1/20 0.30
MAPK11 Q15759 1/20 0.30
MAPK14 Q16539 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29866564 0.85 TYK2 (0.37) MAPTTYK2MAPK13EIF2AK2MAPK12
SCHEMBL25573062 0.85 TYK2 (0.37) MAPTTYK2MAPK13EIF2AK2MAPK12
SCHEMBL29866220 0.83 TYK2 (0.38) TYK2
SCHEMBL29866375 0.81 TYK2 (0.44) TYK2
SCHEMBL29865997 0.79
SCHEMBL30696907 0.78
SCHEMBL29866398 0.78 TDP1 (0.34) MAPT
SCHEMBL29766558 0.76 DRD4 (0.44) MAPT
SCHEMBL26677698 0.75 TYK2 (0.31) TYK2
SCHEMBL29866682 0.73 CHRM2 (0.37) MAPK14

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4532485-A1 TYK2 INHIBITORS AND USES THEREOF Sudo Biosciences Limited (GB) 2025-04-09 EP disclosed
CN-117242072-A TYK2 inhibitor and application thereof 苏多生物科学有限公司 2023-12-15 CN disclosed
WO-2023227946-A1 TYK2 INHIBITORS AND USES THEREOF SUDO BIOSCIENCES LIMITED (GB) 2023-11-30 WO disclosed
WO-2022175747-A1 TYK2 INHIBITORS AND USES THEREOF SUDO BIOSCIENCES LIMITED (GB) 2022-08-25 WO disclosed