Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | CASP3 | P42574 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.36 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.36 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.36 |
| ▸ | KCNA5 | P22460 | 2/20 | 0.36 |
| ▸ | CETP | P11597 | 3/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | EGFR | P00533 | 4/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23084799 | 1.00 | POLB (0.38) | POLBL3MBTL1TSHRCASP3RAB9A | |
| SCHEMBL21121829 | 0.87 | TSHR (0.40) | POLBL3MBTL1TSHRCASP3RAB9A | |
| SCHEMBL29868093 | 0.86 | ALDH1A1 (0.36) | POLBL3MBTL1TSHRKCNA5CETP | |
| SCHEMBL23084690 | 0.86 | ALDH1A1 (0.36) | POLBL3MBTL1TSHRKCNA5CETP | |
| SCHEMBL30270924 | 0.85 | CHRM2 (0.32) | CASP3SENP8SENP7SENP6 | |
| SCHEMBL29868015 | 0.79 | MEN1 (0.38) | L3MBTL1CASP3SENP8SENP7SENP6 | |
| SCHEMBL23084702 | 0.79 | MEN1 (0.38) | L3MBTL1CASP3SENP8SENP7SENP6 | |
| SCHEMBL31555442 | 0.77 | PPARA (0.33) | POLBL3MBTL1TSHRCASP3RAB9A | |
| SCHEMBL23698705 | 0.76 | ALDH1A1 (0.35) | L3MBTL1TSHRCASP3RAB9ASENP8 | |
| SCHEMBL31509839 | 0.76 | L3MBTL1 (0.34) | POLBL3MBTL1TSHRCASP3RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11447449-B2 | Inhibitors of indoleamine 2,3-dioxygenase and methods of their use | BRISTOL-MYERS SQUIBB COMPANY (US) | 2022-09-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11447449-B2 | Inhibitors of indoleamine 2,3-dioxygenase and methods of their use | IDO1, IDO2, INMT | POLB 1958/4885L3MBTL1 3665/4885TSHR 3245/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.