Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 14/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.33 |
| ▸ | NTRK1 | P04629 | 4/20 | 0.33 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.33 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.33 |
| ▸ | JAK2 | O60674 | 1/20 | 0.32 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL756824 | 1.00 | GPR119 (0.38) | GPR119CYP2C9CYP2C19KCNH2NTRK1 | |
| SCHEMBL756571 | 0.95 | GPR119 (0.39) | GPR119CYP2C9CYP2C19JAK2TBK1 | |
| SCHEMBL299860 | 0.95 | GPR119 (0.39) | GPR119CYP2C9CYP2C19JAK2TBK1 | |
| SCHEMBL757863 | 0.93 | GPR119 (0.37) | GPR119CYP2C9CYP2C19JAK2TBK1 | |
| SCHEMBL3510203 | 0.88 | GPR119 (0.38) | GPR119KCNH2NTRK1NTRK3NTRK2 | |
| SCHEMBL757959 | 0.79 | GPR119 (0.48) | GPR119CYP2C9CYP2C19 | |
| SCHEMBL756825 | 0.78 | GPR119 (0.35) | GPR119 | |
| SCHEMBL298847 | 0.77 | GPR119 (0.40) | GPR119CYP2C9CYP2C19JAK2TBK1 | |
| SCHEMBL759976 | 0.77 | GPR119 (0.40) | GPR119CYP2C9CYP2C19JAK2TBK1 | |
| SCHEMBL300340 | 0.77 | GPR119 (0.40) | GPR119CYP2C9CYP2C19JAK2TBK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2427450-A1 | GPR 119 MODULATORS | Pfizer Inc. (US) | 2012-03-14 | — | — | EP | disclosed |
| EP-2427448-A1 | Gpr 119 modulators | Pfizer Inc. (US) | 2012-03-14 | — | — | EP | disclosed |
| WO-2010128425-A1 | GPR 119 MODULATORS | PFIZER INC. (US) | 2010-11-11 | — | — | WO | disclosed |
| WO-2010128414-A1 | GPR 119 MODULATORS | PFIZER INC. (US) | 2010-11-11 | — | — | WO | disclosed |