Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDC7 | O00311 | 2/20 | 0.68 |
| ▸ | DYRK1A | Q13627 | 7/20 | 0.66 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.66 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.64 |
| ▸ | GSK3B | P49841 | 2/20 | 0.63 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.63 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.63 |
| ▸ | PIM1 | P11309 | 1/20 | 0.63 |
| ▸ | PRKACA | P17612 | 1/20 | 0.63 |
| ▸ | CDK2 | P24941 | 1/20 | 0.63 |
| ▸ | HIPK2 | Q9H2X6 | 1/20 | 0.63 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.63 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.63 |
| ▸ | IKBKE | Q14164 | 2/20 | 0.62 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.62 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.62 |
| ▸ | CAMKK2 | Q96RR4 | 2/20 | 0.61 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.60 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.60 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL856823 | 1.00 | CDC7 (0.68) | CDC7DYRK1ADYRK1BNUDT1GSK3B | |
| SCHEMBL29869781 | 0.88 | TGFBR1 (0.60) | CDC7DYRK1ADYRK1BGSK3BROCK2 | |
| SCHEMBL3740263 | 0.86 | CAMKK2 (0.69) | CDC7DYRK1ADYRK1BGSK3BROCK2 | |
| SCHEMBL4831547 | 0.85 | DYRK1A (0.56) | CDC7DYRK1ADYRK1BNUDT1GSK3B | |
| SCHEMBL857678 | 0.84 | IKBKE (0.64) | CDC7DYRK1ADYRK1BGSK3BROCK2 | |
| SCHEMBL20292748 | 0.84 | DYRK1B (0.68) | CDC7DYRK1ADYRK1BNUDT1GSK3B | |
| SCHEMBL29869591 | 0.83 | CDC7 (0.60) | CDC7DYRK1ADYRK1BGSK3BROCK2 | |
| SCHEMBL5618155 | 0.83 | TGFBR1 (0.71) | CDC7DYRK1ADYRK1BGSK3BROCK2 | |
| SCHEMBL858985 | 0.83 | CAMKK2 (0.70) | CDC7DYRK1ADYRK1BGSK3BROCK2 | |
| SCHEMBL19068218 | 0.82 | DYRK1A (0.64) | DYRK1ADYRK1BNTRK1PIK3CACLK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112794851-B | 3- (pyridine-3-yl) -7-azaindole derivative PI3K delta inhibitor and preparation method and application thereof | 复旦大学 | 2022-08-23 | — | — | CN | claimed |
| CN-118164979-A | Azaindole PI3K delta inhibitor, preparation method and application thereof | 浙江大学 | 2024-06-11 | — | — | CN | disclosed |
| CN-112794851-B | 3- (pyridine-3-yl) -7-azaindole derivative PI3K delta inhibitor and preparation method and application thereof | 复旦大学 | 2022-08-23 | — | — | CN | disclosed |
| CN-112794851-B | 3- (pyridine-3-yl) -7-azaindole derivative PI3K delta inhibitor and preparation method and application thereof | 复旦大学 | 2022-08-23 | — | — | CN | disclosed |
| CN-112794851-B | 3- (pyridine-3-yl) -7-azaindole derivative PI3K delta inhibitor and preparation method and application thereof | 复旦大学 | 2022-08-23 | — | — | CN | disclosed |