Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B1 | P14061 | 8/20 | 0.75 |
| ▸ | HSD17B2 | P37059 | 7/20 | 0.75 |
| ▸ | NPC1 | O15118 | 2/20 | 0.63 |
| ▸ | RAB9A | P51151 | 2/20 | 0.63 |
| ▸ | MEN1 | O00255 | 2/20 | 0.63 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.63 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.61 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.61 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.61 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.61 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.61 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.58 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.57 |
| ▸ | DYRK1B | Q9Y463 | 2/20 | 0.57 |
| ▸ | LMNA | P02545 | 2/20 | 0.54 |
| ▸ | MAPT | P10636 | 2/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.54 |
| ▸ | MAOB | P27338 | 1/20 | 0.54 |
| ▸ | SNCA | P37840 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29886 | 0.86 | HSD17B1 (1.00) | HSD17B1HSD17B2NPC1RAB9AMEN1 | |
| SCHEMBL30323 | 0.86 | HSD17B1 (1.00) | HSD17B1HSD17B2NPC1RAB9AMEN1 | |
| SCHEMBL31050 | 0.85 | HSD17B1 (0.68) | HSD17B1HSD17B2NPC1RAB9AMEN1 | |
| SCHEMBL29710 | 0.85 | HSD17B1 (1.00) | HSD17B1HSD17B2NPC1RAB9AMEN1 | |
| SCHEMBL31033 | 0.80 | HSD17B1 (0.76) | HSD17B1HSD17B2NPC1RAB9AMEN1 | |
| SCHEMBL13329184 | 0.80 | HSD17B1 (0.81) | HSD17B1HSD17B2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL13329867 | 0.80 | HSD17B1 (0.66) | HSD17B1HSD17B2NPC1RAB9ACYP3A4 | |
| SCHEMBL12199320 | 0.80 | HSD17B1 (0.81) | HSD17B1HSD17B2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL12199345 | 0.80 | HSD17B1 (0.66) | HSD17B1HSD17B2NPC1RAB9ACYP3A4 | |
| SCHEMBL12199339 | 0.80 | HSD17B1 (0.66) | HSD17B1HSD17B2NPC1RAB9ACYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2609089-A1 | SELECTIVE 17BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1 INHIBITORS | Universität des Saarlandes (DE) | 2013-07-03 | — | — | EP | claimed |
| WO-2012025638-A1 | SELECTIVE 17BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1 INHIBITORS | Universität des Saarlandes (DE) | 2012-03-01 | — | — | WO | claimed |