Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B1 | P14061 | 8/20 | 0.81 |
| ▸ | HSD17B2 | P37059 | 7/20 | 0.81 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.70 |
| ▸ | MAPT | P10636 | 1/20 | 0.69 |
| ▸ | HTT | P42858 | 1/20 | 0.69 |
| ▸ | SNCA | P37840 | 1/20 | 0.67 |
| ▸ | LMNA | P02545 | 1/20 | 0.63 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.63 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.63 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.63 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.63 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.63 |
| ▸ | DYRK1A | Q13627 | 4/20 | 0.61 |
| ▸ | SCD | O00767 | 2/20 | 0.59 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12199320 | 1.00 | HSD17B1 (0.81) | HSD17B1HSD17B2LRRK2MAPTHTT | |
| SCHEMBL31035 | 0.90 | HSD17B1 (1.00) | HSD17B1HSD17B2LRRK2SNCADYRK1A | |
| SCHEMBL24730431 | 0.87 | LRRK2 (0.72) | HSD17B1HSD17B2LRRK2MAPTHTT | |
| SCHEMBL5445832 | 0.87 | HPGDS (0.69) | HSD17B1HSD17B2LRRK2MAPTHTT | |
| SCHEMBL12199338 | 0.87 | HPGDS (0.69) | HSD17B1HSD17B2LRRK2MAPTHTT | |
| SCHEMBL13329187 | 0.87 | HPGDS (0.69) | HSD17B1HSD17B2LRRK2MAPTHTT | |
| SCHEMBL12199323 | 0.86 | HSD17B1 (0.76) | HSD17B1HSD17B2LRRK2MAPTHTT | |
| SCHEMBL12199347 | 0.86 | HSD17B1 (0.76) | HSD17B1HSD17B2LRRK2MAPTHTT | |
| SCHEMBL4909148 | 0.86 | NPC1 (0.74) | HSD17B1HSD17B2LRRK2MAPTHTT | |
| SCHEMBL29788 | 0.86 | HSD17B1 (0.82) | HSD17B1HSD17B2LRRK2MAPTSNCA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010066357-A1 | BENZOTHIAZOLE AMIDES FOR DETECTION OF AMYLOID BETA | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2010-06-17 | — | — | WO | disclosed |