Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 7/20 | 0.49 |
| ▸ | MEN1 | O00255 | 4/20 | 0.49 |
| ▸ | PKM | P14618 | 2/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 8/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.43 |
| ▸ | HPGD | P15428 | 6/20 | 0.43 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | THRB | P10828 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | GSK3A | P49840 | 1/20 | 0.42 |
| ▸ | GSK3B | P49841 | 1/20 | 0.42 |
| ▸ | BRAF | P15056 | 1/20 | 0.41 |
| ▸ | INSR | P06213 | 1/20 | 0.41 |
| ▸ | IGF1R | P08069 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2905363 | 0.80 | KMT2A (0.50) | KMT2AMEN1PKMNPSR1KDM4E | |
| SCHEMBL2910797 | 0.78 | MAPT (0.56) | KMT2AMEN1NPSR1MAPTALDH1A1 | |
| SCHEMBL2911361 | 0.77 | MAPT (0.58) | KMT2AMEN1KDM4EMAPTALDH1A1 | |
| SCHEMBL16268566 | 0.76 | MAPT (0.57) | KMT2AMEN1KDM4EMAPTALDH1A1 | |
| SCHEMBL7538746 | 0.76 | LMNA (0.54) | KMT2AMEN1NPSR1KDM4EMAPT | |
| SCHEMBL5145199 | 0.75 | KMT2A (0.79) | KMT2AMEN1PKMNPSR1KDM4E | |
| SCHEMBL976342 | 0.74 | MAPT (0.62) | KMT2AMEN1PKMNPSR1KDM4E | |
| SCHEMBL2909012 | 0.71 | INSR (0.50) | KMT2AMEN1NPSR1KDM4EMAPT | |
| SCHEMBL2903627 | 0.70 | KMT2A (0.52) | KMT2AMEN1PKMNPSR1KDM4E | |
| SCHEMBL2911157 | 0.67 | MEN1 (0.38) | KMT2AMEN1KDM4EMAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2219605-A1 | CO-SOLVENT COMPOSITIONS AND METHODS FOR IMPROVED DELIVERY OF DANTROLENE THERAPEUTIC AGENTS | US Worldmeds LLC (US) | 2010-08-25 | — | — | EP | claimed |
| WO-2009048698-A9 | CO-SOLVENT COMPOSITIONS AND METHODS FOR IMPROVED DELIVERY OF DANTROLENE THERAPEUTIC AGENTS | US WORLDMEDS LLC (US) | 2009-11-19 | — | — | WO | claimed |
| WO-2009048698-A1 | CO-SOLVENT COMPOSITIONS AND METHODS FOR IMPROVED DELIVERY OF DANTROLENE THERAPEUTIC AGENTS | US WORLDMEDS LLC (US) | 2009-04-16 | — | — | WO | claimed |