Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CAMKK2 | Q96RR4 | 2/20 | 0.57 |
| ▸ | PLK4 | O00444 | 2/20 | 0.43 |
| ▸ | AXL | P30530 | 2/20 | 0.43 |
| ▸ | CDC7 | O00311 | 1/20 | 0.43 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.43 |
| ▸ | AURKA | O14965 | 1/20 | 0.43 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.43 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.43 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.43 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.43 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.43 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.43 |
| ▸ | PAK4 | O96013 | 1/20 | 0.43 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.43 |
| ▸ | ABL1 | P00519 | 1/20 | 0.43 |
| ▸ | EGFR | P00533 | 1/20 | 0.43 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.43 |
| ▸ | INSR | P06213 | 1/20 | 0.43 |
| ▸ | LCK | P06239 | 1/20 | 0.43 |
| ▸ | FYN | P06241 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL299489 | 0.85 | PAK1 (0.49) | PDPK1PAK4PAK1TNIK | |
| SCHEMBL298555 | 0.84 | CYP2C19 (0.41) | CAMKK2PLK4AXLCDC7CHEK1 | |
| SCHEMBL297910 | 0.83 | CYP2C19 (0.41) | CAMKK2PLK4AXLCDC7CHEK1 | |
| SCHEMBL298748 | 0.82 | BRAF (0.41) | PLK4AXLCDC7CHEK1AURKA | |
| SCHEMBL298502 | 0.82 | PAK1 (0.39) | CAMKK2PLK4AXLCDC7CHEK1 | |
| SCHEMBL3702186 | 0.82 | CAMKK2 (0.67) | CAMKK2PLK4AXLCDC7CHEK1 | |
| SCHEMBL299342 | 0.82 | AAK1 (0.38) | CAMKK2AXLDYRK3ROCK2PRKD3 | |
| SCHEMBL298126 | 0.81 | BRAF (0.42) | PLK4AXLCDC7CHEK1AURKA | |
| SCHEMBL299063 | 0.81 | PAK1 (0.40) | CAMKK2PLK4AXLCDC7CHEK1 | |
| SCHEMBL3702374 | 0.81 | CAMKK2 (0.69) | CAMKK2PLK4AXLCDC7CHEK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2427433-A1 | SOLID FORMS OF SULFONAMIDES AND AMINO ACIDS | Plexxikon, Inc. (US) | 2012-03-14 | — | — | EP | disclosed |