Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AAK1 | Q2M2I8 | 2/20 | 0.38 |
| ▸ | PAK1 | Q13153 | 6/20 | 0.36 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.36 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.36 |
| ▸ | MAP3K11 | Q16584 | 1/20 | 0.35 |
| ▸ | AXL | P30530 | 3/20 | 0.33 |
| ▸ | CAMKK2 | Q96RR4 | 2/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.33 |
| ▸ | CLK1 | P49759 | 1/20 | 0.33 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.33 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.33 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.33 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.33 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.33 |
| ▸ | EGFR | P00533 | 1/20 | 0.33 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.33 |
| ▸ | CDK1 | P06493 | 1/20 | 0.33 |
| ▸ | FES | P07332 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL297236 | 0.99 | AAK1 (0.39) | AAK1PAK1MTNR1AMTNR1BMAP3K11 | |
| SCHEMBL298555 | 0.89 | CYP2C19 (0.41) | AAK1PAK1MAP3K11AXLCAMKK2 | |
| SCHEMBL297910 | 0.88 | CYP2C19 (0.41) | AAK1PAK1MAP3K11AXLCAMKK2 | |
| SCHEMBL298502 | 0.87 | PAK1 (0.39) | PAK1MAP3K11AXLCAMKK2CYP2C9 | |
| SCHEMBL298748 | 0.87 | BRAF (0.41) | PAK1AXLCYP2C9DYRK1ACLK1 | |
| SCHEMBL298126 | 0.86 | BRAF (0.42) | PAK1MAP3K11AXLCYP2C9DYRK1A | |
| SCHEMBL299063 | 0.86 | PAK1 (0.40) | PAK1MAP3K11AXLCAMKK2CYP2C9 | |
| SCHEMBL299489 | 0.83 | PAK1 (0.49) | PAK1MKNK2 | |
| SCHEMBL297099 | 0.82 | BRAF (0.43) | PAK1MAP3K11AXLCAMKK2CYP2C9 | |
| SCHEMBL298746 | 0.82 | CAMKK2 (0.57) | AAK1PAK1MAP3K11AXLCAMKK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2427433-A1 | SOLID FORMS OF SULFONAMIDES AND AMINO ACIDS | Plexxikon, Inc. (US) | 2012-03-14 | — | — | EP | disclosed |