Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 7/20 | 0.41 |
| ▸ | PAK1 | Q13153 | 7/20 | 0.41 |
| ▸ | KDR | P35968 | 3/20 | 0.41 |
| ▸ | NEK2 | P51955 | 3/20 | 0.41 |
| ▸ | RIPK2 | O43353 | 2/20 | 0.41 |
| ▸ | RAF1 | P04049 | 2/20 | 0.41 |
| ▸ | MAP2K2 | P36507 | 2/20 | 0.41 |
| ▸ | TGFBR2 | P37173 | 2/20 | 0.41 |
| ▸ | MAP2K1 | Q02750 | 2/20 | 0.41 |
| ▸ | TNK2 | Q07912 | 2/20 | 0.41 |
| ▸ | MAP2K5 | Q13163 | 2/20 | 0.41 |
| ▸ | PTK6 | Q13882 | 2/20 | 0.41 |
| ▸ | NEK11 | Q8NG66 | 2/20 | 0.41 |
| ▸ | MAP3K20 | Q9NYL2 | 2/20 | 0.41 |
| ▸ | MAP4K5 | Q9Y4K4 | 2/20 | 0.41 |
| ▸ | PLK4 | O00444 | 2/20 | 0.41 |
| ▸ | AURKA | O14965 | 2/20 | 0.41 |
| ▸ | ABL1 | P00519 | 2/20 | 0.41 |
| ▸ | LCK | P06239 | 2/20 | 0.41 |
| ▸ | FYN | P06241 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL298126 | 0.99 | BRAF (0.42) | BRAFPAK1KDRNEK2RIPK2 | |
| SCHEMBL297099 | 0.95 | BRAF (0.43) | BRAFPAK1KDRNEK2RIPK2 | |
| SCHEMBL298502 | 0.89 | PAK1 (0.39) | BRAFPAK1KDRNEK2RIPK2 | |
| SCHEMBL298555 | 0.89 | CYP2C19 (0.41) | BRAFPAK1KDRNEK2RIPK2 | |
| SCHEMBL297910 | 0.88 | CYP2C19 (0.41) | BRAFPAK1KDRNEK2RIPK2 | |
| SCHEMBL299063 | 0.88 | PAK1 (0.40) | BRAFPAK1KDRNEK2RIPK2 | |
| SCHEMBL299342 | 0.87 | AAK1 (0.38) | PAK1PTK6MAP3K20MAP4K5FES | |
| SCHEMBL297236 | 0.86 | AAK1 (0.39) | PAK1KDRNEK2PTK6MAP3K20 | |
| SCHEMBL299489 | 0.83 | PAK1 (0.49) | PAK1TNIKPDPK1PAK4 | |
| SCHEMBL298746 | 0.82 | CAMKK2 (0.57) | PAK1KDRNEK2PLK4AURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2427433-A1 | SOLID FORMS OF SULFONAMIDES AND AMINO ACIDS | Plexxikon, Inc. (US) | 2012-03-14 | — | — | EP | disclosed |