Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.54 |
| ▸ | NPC1 | O15118 | 1/20 | 0.54 |
| ▸ | RAB9A | P51151 | 1/20 | 0.54 |
| ▸ | CTSL | P07711 | 3/20 | 0.42 |
| ▸ | SNCA | P37840 | 4/20 | 0.39 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.38 |
| ▸ | PNMT | P11086 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | NOX1 | Q9Y5S8 | 1/20 | 0.36 |
| ▸ | TDP2 | O95551 | 1/20 | 0.36 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.36 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.36 |
| ▸ | CAPN9 | O14815 | 1/20 | 0.36 |
| ▸ | CASP3 | P42574 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL499310 | 0.91 | MAPT (0.56) | MAPTNPC1RAB9ACTSLSNCA | |
| SCHEMBL8471691 | 0.81 | MAPT (0.59) | MAPTNPC1RAB9ASNCAADRA2A | |
| SCHEMBL499539 | 0.80 | SNCA (0.49) | MAPTNPC1RAB9ACTSLSNCA | |
| SCHEMBL11268349 | 0.75 | PNMT (0.43) | MAPTNPC1RAB9ACTSLSNCA | |
| SCHEMBL24982 | 0.73 | MAPT (0.49) | MAPTNPC1RAB9ACTSLSNCA | |
| SCHEMBL29581896 | 0.73 | PNMT (0.51) | MAPTNPC1RAB9ACTSLADRA2A | |
| SCHEMBL395008 | 0.73 | PNMT (0.51) | MAPTNPC1RAB9ACTSLADRA2A | |
| SCHEMBL29414930 | 0.73 | CTSL (0.50) | MAPTNPC1RAB9ACTSLADRA2A | |
| SCHEMBL5520219 | 0.72 | ALDH1A1 (0.42) | MAPTNPC1RAB9ACTSLMEN1 | |
| SCHEMBL5636666 | 0.72 | ALDH1A1 (0.42) | MAPTCTSLMEN1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022213975-A1 | COMPOUNDS TARGETING Y220C MUTANT OF P53 | JACOBIO PHARMACEUTICALS CO., LTD. (CN) | 2022-10-13 | — | — | WO | disclosed |