Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR2 | Q92731 | 1/20 | 0.40 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | CTSK | P43235 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.35 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.35 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.35 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29877791 | 0.87 | ESR2 (0.36) | ESR2NR1H2USP2SMN1; SMN2CTSK | |
| SCHEMBL12465383 | 0.85 | ESR2 (0.37) | ESR2NR1H2USP2SMN1; SMN2CTSK | |
| SCHEMBL29877639 | 0.79 | ESR2 (0.36) | ESR2GPR119 | |
| SCHEMBL2980997 | 0.77 | ESR2 (0.43) | ESR2NR1H2USP2SMN1; SMN2CTSK | |
| SCHEMBL17481737 | 0.77 | USP2 (0.41) | ESR2NR1H2USP2SMN1; SMN2CTSK | |
| SCHEMBL2002272 | 0.76 | PDK4 (0.48) | ESR2NR1H2USP2SMN1; SMN2GPR119 | |
| SCHEMBL20690515 | 0.76 | ALDH1A1 (0.40) | ESR2NR1H2USP2SMN1; SMN2CTSK | |
| SCHEMBL26134753 | 0.75 | USP2 (0.44) | ESR2NR1H2USP2SMN1; SMN2GPR119 | |
| SCHEMBL28584444 | 0.75 | MAPT (0.45) | GPR119MAPTKDM4EALDH1A1 | |
| SCHEMBL17942084 | 0.75 | GPR119 (0.39) | ESR2NR1H2USP2SMN1; SMN2CTSK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116888108-B | Novel EGFR degradation agent | 上海齐鲁制药研究中心有限公司 | 2024-04-19 | — | — | CN | disclosed |
| CN-116888108-A | Novel EGFR degradation agent | 上海齐鲁制药研究中心有限公司 | 2023-10-13 | — | — | CN | disclosed |
| WO-2022194269-A1 | NOVEL EGFR DEGRADATION AGENT | 上海齐鲁制药研究中心有限公司 | 2022-09-22 | — | — | WO | disclosed |