Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR2 | Q92731 | 1/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.39 |
| ▸ | GPR119 | Q8TDV5 | 5/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | CTSK | P43235 | 1/20 | 0.37 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.36 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.36 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3505154 | 0.85 | ESR2 (0.45) | ESR2USP2SMN1; SMN2NR1H2GPR119 | |
| SCHEMBL17481737 | 0.81 | USP2 (0.41) | ESR2USP2SMN1; SMN2NR1H2GPR119 | |
| SCHEMBL18499551 | 0.80 | USP2 (0.49) | ESR2USP2SMN1; SMN2NR1H2GPR119 | |
| SCHEMBL20690515 | 0.80 | ALDH1A1 (0.40) | ESR2USP2SMN1; SMN2NR1H2GPR119 | |
| SCHEMBL17942084 | 0.79 | GPR119 (0.39) | ESR2USP2SMN1; SMN2NR1H2GPR119 | |
| SCHEMBL17942066 | 0.77 | USP2 (0.41) | ESR2USP2SMN1; SMN2NR1H2GPR119 | |
| SCHEMBL29877296 | 0.77 | ESR2 (0.40) | ESR2USP2SMN1; SMN2NR1H2GPR119 | |
| SCHEMBL12465383 | 0.76 | ESR2 (0.37) | ESR2USP2SMN1; SMN2NR1H2GPR119 | |
| SCHEMBL17942035 | 0.76 | HTT (0.37) | ESR2USP2SMN1; SMN2NR1H2GPR119 | |
| SCHEMBL14878683 | 0.75 | USP2 (0.39) | ESR2USP2SMN1; SMN2NR1H2GPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-119320379-A | Indazole derivative, preparation method and medical application thereof | 江苏恒瑞医药股份有限公司 | 2025-01-17 | — | — | CN | disclosed |
| CN-113874367-B | Indazole derivative, preparation method and medical application thereof | 江苏恒瑞医药股份有限公司 | 2024-09-13 | — | — | CN | disclosed |
| US-11713313-B2 | GLS1 inhibitors for treating disease | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 2023-08-01 | — | — | US | disclosed |
| US-20210122744-A1 | GLS1 INHIBITORS FOR TREATING DISEASE | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM | 2021-04-29 | — | — | US | disclosed |
| US-10738043-B2 | GLS1 inhibitors for treating disease | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 2020-08-11 | — | — | US | disclosed |
| EP-3316887-B1 | GLS1 INHIBITORS FOR TREATING DISEASE | UNIV TEXAS (US) | 2020-04-08 | — | — | EP | disclosed |
| US-20190031651-A1 | GLS1 INHIBITORS FOR TREATING DISEASE | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM | 2019-01-31 | — | — | US | disclosed |
| EP-1950198-B1 | PROCESS FOR PRODUCTION OF BENZYLOXYPYRROLIDINE DERIVATIVE, AND PROCESS FOR PRODUCTION OF HYDROCHLORIDE SALT POWDER OF OPTICALLY ACTIVE BENZYLOXYPYRROLIDINE DERIVATIVE | TORAY FINECHEMICALS CO LTD (JP) | 2014-08-06 | — | — | EP | disclosed |
| US-7772406-B2 | Process for production of benzyloxypyrrolidine derivative, and process for production of hydrochloride salt powder of optically active benzyloxypyrrolidine derivative | TORAY FINE CHEMICALS CO., LTD. (JP) | 2010-08-10 | — | — | US | disclosed |
| US-20090093643-A1 | Process for Production of Benzyloxypyrrolidine Derivative, and Process for Production of Hydrochloride Salt Powder of Optically Active Benzyloxypyrrolidine Derivative | TORAY FINE CHEMICALS CO., LTD. (JP) | 2009-04-09 | — | — | US | disclosed |
| EP-1950198-A1 | PROCESS FOR PRODUCTION OF BENZYLOXYPYRROLIDINE DERIVATIVE, AND PROCESS FOR PRODUCTION OF HYDROCHLORIDE SALT POWDER OF OPTICALLY ACTIVE BENZYLOXYPYRROLIDINE DERIVATIVE | Toray Fine Chemicals Co., Ltd. (JP) | 2008-07-30 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10738043-B2 | GLS1 inhibitors for treating disease | GLS2, GLS, GLG1 | ESR2 3385/4885USP2 2989/4885SMN1; SMN2 2191/4885 |
| US-20190031651-A1 | GLS1 INHIBITORS FOR TREATING DISEASE | GLS2, GLS, GLG1 | ESR2 3385/4885USP2 2989/4885SMN1; SMN2 2191/4885 |
| US-20210122744-A1 | GLS1 INHIBITORS FOR TREATING DISEASE | GLS2, GLS, GLG1 | ESR2 3385/4885USP2 2989/4885SMN1; SMN2 2191/4885 |
| US-11713313-B2 | GLS1 inhibitors for treating disease | GLS2, GLS, GLG1 | ESR2 3385/4885USP2 2989/4885SMN1; SMN2 2191/4885 |
| US-20090093643-A1 | Process for Production of Benzyloxypyrrolidine Derivative, and Process for Production of Hydrochloride Salt Powder of Optically Active Benzyloxypyrrolidine Derivative | HPD, PAH, DHPS | ESR2 4570/4885USP2 3655/4885SMN1; SMN2 2993/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.