Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ASPH | Q12797 | 4/20 | 0.44 |
| ▸ | KDM8 | Q8N371 | 3/20 | 0.44 |
| ▸ | KMO | O15229 | 10/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | HCAR2 | Q8TDS4 | 2/20 | 0.41 |
| ▸ | RIOX2 | Q8IUF8 | 1/20 | 0.38 |
| ▸ | P4HA1 | P13674 | 1/20 | 0.35 |
| ▸ | MIF | P14174 | 1/20 | 0.35 |
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.35 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.35 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.35 |
| ▸ | KDM5A | P29375 | 1/20 | 0.35 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15776120 | 0.86 | ASPH (0.44) | ASPHKDM8KMOKDM4EGLA | |
| SCHEMBL29878040 | 0.81 | MAPK1 (0.41) | KDM4E | |
| SCHEMBL21616744 | 0.77 | ASPH (0.45) | ASPHKDM8KMOKDM4EGLA | |
| SCHEMBL29712296 | 0.75 | KMO (0.52) | ASPHKDM8KMOKDM4ESMN1; SMN2 | |
| SCHEMBL3408592 | 0.75 | KMO (0.52) | ASPHKDM8KMOKDM4ESMN1; SMN2 | |
| SCHEMBL20772273 | 0.75 | CYP17A1 (0.40) | KMT2A | |
| SCHEMBL23612070 | 0.74 | CNR2 (0.38) | ASPHKDM8KMOKDM4EGLA | |
| SCHEMBL29989008 | 0.74 | CNR2 (0.38) | ASPHKDM8KMOKDM4EGLA | |
| SCHEMBL30703822 | 0.73 | ASPH (0.45) | ASPHKDM8KMOKDM4EGLA | |
| SCHEMBL24660110 | 0.73 | ASPH (0.40) | ASPHKDM8KMOKDM4EGLA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240317752-A1 | 6-SUBSTITUTED-9H-PURINE DERIVATIVES AND RELATED USES | BLACK DIAMOND THERAPEUTICS, INC. (US) | 2024-09-26 | — | — | US | disclosed |
| WO-2022178256-A1 | 6-SUBSTITUTED-9H-PURINE DERIVATIVES AND RELATED USES | BLACK DIAMOND THERAPEUTICS, INC. (US) | 2022-08-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240317752-A1 | 6-SUBSTITUTED-9H-PURINE DERIVATIVES AND RELATED USES | TYMP, DPYD, PNP | ASPH 3059/4885KDM8 3935/4885KMO 2930/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.