Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP1 | O94782 | 12/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.37 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.37 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.37 |
| ▸ | PDE2A | O00408 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.34 |
| ▸ | CSF1R | P07333 | 1/20 | 0.34 |
| ▸ | BCDIN3D | Q7Z5W3 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27031623 | 1.00 | USP1 (0.39) | USP1HDAC1HDAC8HDAC6HDAC5 | |
| SCHEMBL27097114 | 0.96 | USP1 (0.37) | USP1HDAC1HDAC8HDAC6HDAC5 | |
| SCHEMBL29879061 | 0.92 | CSF1R (0.38) | USP1PDE2ACSF1R | |
| SCHEMBL27031470 | 0.92 | CSF1R (0.38) | USP1PDE2ACSF1R | |
| SCHEMBL25430986 | 0.89 | USP1 (0.38) | USP1HDAC1HDAC8HDAC6HDAC5 | |
| SCHEMBL27031506 | 0.89 | CSF1R (0.36) | USP1PDE2ACSF1R | |
| SCHEMBL29878443 | 0.89 | CSF1R (0.36) | USP1PDE2ACSF1R | |
| SCHEMBL30032845 | 0.89 | USP1 (0.39) | USP1HDAC1HDAC8HDAC6HDAC5 | |
| SCHEMBL29296027 | 0.89 | USP1 (0.39) | USP1HDAC1HDAC8HDAC6HDAC5 | |
| SCHEMBL25978768 | 0.89 | USP1 (0.39) | USP1HDAC1HDAC8HDAC6HDAC5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4308566-A1 | PURINE DERIVATIVES AS ANTICANCER AGENTS | Tango Therapeutics, Inc. (US) | 2024-01-24 | — | — | EP | disclosed |
| CN-117425656-A | Purine derivatives as anticancer agents | 探戈医药股份有限公司 | 2024-01-19 | — | — | CN | disclosed |
| WO-2022197892-A1 | PURINE DERIVATIVES AS ANTICANCER AGENTS | TANGO THERAPEUTICS, INC. (US) | 2022-09-22 | — | — | WO | disclosed |