Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RET | P07949 | 10/20 | 0.38 |
| ▸ | ELANE | P08246 | 1/20 | 0.35 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.35 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.35 |
| ▸ | EPHB3 | P54753 | 1/20 | 0.35 |
| ▸ | PIM1 | P11309 | 1/20 | 0.35 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.35 |
| ▸ | PARP1 | P09874 | 1/20 | 0.33 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.33 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.33 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.33 |
| ▸ | CSNK2A1 | P68400 | 2/20 | 0.33 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30129680 | 0.86 | RET (0.35) | RETELANESCN5ASCN9ACSNK2A1 | |
| SCHEMBL28848982 | 0.86 | RET (0.35) | RETELANESCN5ASCN9ACSNK2A1 | |
| SCHEMBL29878473 | 0.85 | EPHB3 (0.38) | RETELANEEPHB3 | |
| SCHEMBL31484050 | 0.75 | PIK3CA (0.34) | RET | |
| SCHEMBL30701033 | 0.74 | BUB1 (0.43) | PIM1PIM2PARP1TNKS2PARP2 | |
| SCHEMBL31484164 | 0.74 | MAPT (0.35) | RET | |
| SCHEMBL24001751 | 0.74 | UCHL1 (0.45) | ELANEPIM1PIM2PARP1TNKS2 | |
| SCHEMBL31330330 | 0.74 | STS (0.40) | PIM1PIM2PARP1TNKS2PARP2 | |
| SCHEMBL31484084 | 0.73 | MAPT (0.34) | RET | |
| SCHEMBL31484108 | 0.73 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115611925-A | HPK1 inhibitors and uses thereof | 轩竹生物科技股份有限公司 | 2023-01-17 | — | — | CN | disclosed |
| CN-114940683-B | HPK1 inhibitors and uses thereof | 轩竹(北京)医药科技有限公司 | 2023-01-17 | — | — | CN | disclosed |
| CN-114940683-A | HPK1 inhibitors and uses thereof | 轩竹(北京)医药科技有限公司 | 2022-08-26 | — | — | CN | disclosed |