SCHEMBL29882152

SCHEMBL29882152

CCc1ncnc(NCCOc2ncccc2Cl)c1Cl

nearest known ligand 0.37

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GAA P10253 1/20 0.37
NPC1 O15118 2/20 0.36
RAB9A P51151 1/20 0.36
ALDH1A1 P00352 3/20 0.36
SMN1; SMN2 Q16637 2/20 0.36
KDM4E B2RXH2 2/20 0.36
PIK3CD O00329 1/20 0.36
PIK3R1 P27986 1/20 0.36
KMT2A Q03164 3/20 0.35
LDHA P00338 1/20 0.35
HSD17B10 Q99714 3/20 0.34
HTT P42858 1/20 0.34
GCK P35557 1/20 0.33
CCR4 P51679 3/20 0.33
MEN1 O00255 2/20 0.33
LMNA P02545 1/20 0.33
CYP1A2 P05177 1/20 0.33
CYP3A4 P08684 1/20 0.33
HIF1A Q16665 1/20 0.33
CLK4 Q9HAZ1 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28673572 1.00 GAA (0.37) GAANPC1RAB9AALDH1A1SMN1; SMN2
SCHEMBL29236604 0.82 HTT (0.36) GAARAB9AALDH1A1SMN1; SMN2KDM4E
SCHEMBL28687252 0.81 CRHR1 (0.36) NPC1RAB9AALDH1A1SMN1; SMN2KDM4E
SCHEMBL28765554 0.79 ACACB (0.35) GAANPC1RAB9AKDM4EKMT2A
SCHEMBL28765556 0.79 ACACB (0.35) GAANPC1RAB9AKDM4EKMT2A
SCHEMBL30039342 0.79 ACACB (0.35) GAANPC1RAB9AKDM4EKMT2A
SCHEMBL28679617 0.77 BCHE (0.36) NPC1RAB9AALDH1A1SMN1; SMN2KDM4E
SCHEMBL28697524 0.77 LDHA (0.60) GAARAB9AALDH1A1SMN1; SMN2KDM4E
SCHEMBL28681165 0.76 POLB (0.42) RAB9AALDH1A1SMN1; SMN2KDM4EKMT2A
SCHEMBL9471998 0.76 PIK3CD (0.51) NPC1RAB9AALDH1A1PIK3CDPIK3R1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-113754638-B Azaether compound containing pyrimidinamine 湖南化工研究院有限公司 2022-10-18 CN disclosed