Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DNMT1 | P26358 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.42 |
| ▸ | TSHR | P16473 | 3/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.42 |
| ▸ | CYP2A6 | P11509 | 2/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | HPRT1 | P00492 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | S100A4 | P26447 | 1/20 | 0.39 |
| ▸ | ANPEP | P15144 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.38 |
| ▸ | WDR5 | P61964 | 1/20 | 0.37 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.37 |
| ▸ | CES1 | P23141 | 3/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31045609 | 0.81 | DNMT1 (0.69) | DNMT1ALDH1A1TSHRHSD17B10CYP2A6 | |
| SCHEMBL5047700 | 0.81 | DNMT1 (0.69) | DNMT1ALDH1A1TSHRHSD17B10CYP2A6 | |
| SCHEMBL14777719 | 0.78 | DNMT1 (0.64) | DNMT1ALDH1A1TSHRHSD17B10CYP2A6 | |
| SCHEMBL30692007 | 0.74 | DNMT1 (0.61) | DNMT1ALDH1A1TSHRHSD17B10CYP2A6 | |
| SCHEMBL31174009 | 0.73 | DNMT1 (1.00) | DNMT1ALDH1A1TSHRHSD17B10CYP2A6 | |
| SCHEMBL1055754 | 0.73 | DNMT1 (1.00) | DNMT1ALDH1A1TSHRHSD17B10CYP2A6 | |
| SCHEMBL29440308 | 0.73 | DNMT1 (0.92) | DNMT1ALDH1A1TSHRHSD17B10CYP2A6 | |
| SCHEMBL2175783 | 0.73 | DNMT1 (0.92) | DNMT1ALDH1A1TSHRHSD17B10CYP2A6 | |
| SCHEMBL30375875 | 0.73 | DNMT1 (0.92) | DNMT1ALDH1A1TSHRHSD17B10CYP2A6 | |
| SCHEMBL196007 | 0.72 | DNMT1 (0.59) | DNMT1ALDH1A1TSHRHSD17B10CYP2A6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 46 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9969858-B2 | Metalloinsertor conjugates | CALIFORNIA INSTITUTE OF TECHNOLOGY (US) | 2018-05-15 | — | — | US | claimed |
| US-20160222043-A1 | METALLOINSERTOR CONJUGATES | CALIFORNIA INSTITUTE OF TECHNOLOGY | 2016-08-04 | — | — | US | claimed |
| US-9051345-B2 | Metalloinsertor complexes targeted to DNA mismatches | CALIFORNIA INSTITUTE OF TECHNOLOGY (US) | 2015-06-09 | — | — | US | claimed |
| US-8859533-B2 | Metalloinsertor complexes targeted to DNA mismatches | CALIFORNIA INSTITUTE OF TECHNOLOGY (US) | 2014-10-14 | — | — | US | claimed |
| EP-2707377-A2 | METALLOINSERTOR COMPLEXES TARGETED TO DNA MISMATCHES | California Institute of Technology (US) | 2014-03-19 | — | — | EP | claimed |
| US-20130345189-A1 | METALLOINSERTOR COMPLEXES TARGETED TO DNA MISMATCHES | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2013-12-26 | — | — | US | claimed |
| US-20130090319-A1 | METALLOINSERTOR COMPLEXES TARGETED TO DNA MISMATCHES | CALIFORNIA INSTITUTE OF TECHNOLOGY | 2013-04-11 | — | — | US | claimed |
| WO-2012155004-A2 | METALLOINSERTOR COMPLEXES TARGETED TO DNA MISMATCHES | CALIFORNIA INSITUTE OF TECHNOLOGY (US) | 2012-11-15 | — | — | WO | claimed |
| US-7786298-B2 | Compounds and methods for nucleic acid mismatch detection | CALIFORNIA INSTITUTE OF TECHNOLOGY (US) | 2010-08-31 | — | — | US | claimed |
| US-20070224612-A1 | Compounds and methods for nucleic acid mismatch detection | CALIFORNIA INSTITUTE OF TECHNOLOGY (US) | 2007-09-27 | — | — | US | claimed |
| WO-2007084380-A2 | COMPOUNDS AND METHODS FOR NUCLEIC ACID MISMATCH DETECTION | CALIFORNIA INSTITUTE OF TECHNOLOGY (US) | 2007-07-26 | — | — | WO | claimed |
| CN-108290905-B | Method for targeting mismatched DNA by adopting d8 square plane metal complex | 香港大学 | 2020-11-06 | — | — | CN | disclosed |
| US-9969858-B2 | Metalloinsertor conjugates | CALIFORNIA INSTITUTE OF TECHNOLOGY (US) | 2018-05-15 | — | — | US | disclosed |
| US-9969858-B2 | Metalloinsertor conjugates | CALIFORNIA INSTITUTE OF TECHNOLOGY (US) | 2018-05-15 | — | — | US | disclosed |
| US-9969858-B2 | Metalloinsertor conjugates | CALIFORNIA INSTITUTE OF TECHNOLOGY (US) | 2018-05-15 | — | — | US | disclosed |
| WO-2007084380-A2 | COMPOUNDS AND METHODS FOR NUCLEIC ACID MISMATCH DETECTION | CALIFORNIA INSTITUTE OF TECHNOLOGY (US) | 2007-07-26 | — | — | WO | disclosed |
| WO-2007084380-A2 | COMPOUNDS AND METHODS FOR NUCLEIC ACID MISMATCH DETECTION | CALIFORNIA INSTITUTE OF TECHNOLOGY (US) | 2007-07-26 | — | — | WO | disclosed |
| WO-2002057492-A9 | METHODS AND COMPOSITIONS FOR DETECTING POLYNUCLEOTIDE DUPLEX DAMAGE | CALIFORNIA INST OF TECHN (US) | 2003-12-18 | — | — | WO | disclosed |
| EP-1349962-A1 | METHODS AND COMPOSITIONS FOR DETECTING POLYNUCLEOTIDE DUPLEX DAMAGE | CALIFORNIA INSTITUTE OF TECHNOLOGY (US) | 2003-10-08 | — | — | EP | disclosed |
| WO-2002057492-A1 | METHODS AND COMPOSITIONS FOR DETECTING POLYNUCLEOTIDE DUPLEX DAMAGE | CALIFORNIA INSTITUTE OF TECHNOLOGY (US) | 2002-07-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070224612-A1 | Compounds and methods for nucleic acid mismatch detection | PCNA, ERCC4, MSH6 | DNMT1 68/4885ALDH1A1 614/4885TSHR 4225/4885 |
| US-20160222043-A1 | METALLOINSERTOR CONJUGATES | MSH2, MSH6, LIG1 | DNMT1 290/4885ALDH1A1 209/4885TSHR 2747/4885 |
| US-20130090319-A1 | METALLOINSERTOR COMPLEXES TARGETED TO DNA MISMATCHES | MSH2, MSH6, PMS2 | DNMT1 66/4885ALDH1A1 2639/4885TSHR 2644/4885 |
| US-20130345189-A1 | METALLOINSERTOR COMPLEXES TARGETED TO DNA MISMATCHES | MSH2, MSH6, PMS2 | DNMT1 66/4885ALDH1A1 2639/4885TSHR 2644/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.