Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | KDR | P35968 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | DHODH | Q02127 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | GMNN | O75496 | 1/20 | 0.39 |
| ▸ | TTR | P02766 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.39 |
| ▸ | UGT1A1 | P22309 | 1/20 | 0.39 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.39 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.39 |
| ▸ | TEAD4 | Q15561 | 1/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23389117 | 1.00 | POLB (0.41) | POLBKDRLMNADHODHMEN1 | |
| SCHEMBL23388911 | 0.88 | RAB9A (0.37) | POLBLMNADHODHMEN1ALDH1A1 | |
| SCHEMBL29888546 | 0.83 | KDR (0.44) | POLBKDRLMNADHODHMEN1 | |
| SCHEMBL23388897 | 0.83 | KDR (0.44) | POLBKDRLMNADHODHMEN1 | |
| SCHEMBL23389045 | 0.78 | LMNA (0.43) | POLBKDRLMNADHODHMEN1 | |
| SCHEMBL29888559 | 0.78 | LMNA (0.43) | POLBKDRLMNADHODHMEN1 | |
| SCHEMBL23388914 | 0.74 | JAK2 (0.39) | DHODHTRPV1MAPTJAK2JAK1 | |
| SCHEMBL23423434 | 0.73 | LMNA (0.46) | POLBKDRLMNADHODHMEN1 | |
| SCHEMBL23388931 | 0.73 | MAPK8 (0.38) | MEN1KMT2APTGS1RAB9AMAPT | |
| SCHEMBL29888533 | 0.71 | MEN1 (0.38) | POLBKDRLMNADHODHMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4061364-A1 | HETEROARYL COMPOUNDS | Vivace Therapeutics, Inc. (US) | 2022-09-28 | — | — | EP | disclosed |