Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN2B | Q13224 | 15/20 | 0.38 |
| ▸ | RXRA | P19793 | 14/20 | 0.38 |
| ▸ | GRIN1 | Q05586 | 14/20 | 0.38 |
| ▸ | MAOB | P27338 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.36 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.36 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL983298 | 1.00 | GRIN2B (0.38) | GRIN2BRXRAGRIN1MAOBKMT2A | |
| SCHEMBL7779435 | 0.83 | ESR1 (0.38) | KMT2AALDH1A1MAPT | |
| SCHEMBL27859538 | 0.82 | MAOB (0.41) | MAOBADRA2AADRA2BADRA2CLMNA | |
| SCHEMBL28043602 | 0.78 | GRIN2B (0.40) | GRIN2BRXRAGRIN1KMT2AALDH1A1 | |
| SCHEMBL363523 | 0.78 | HSD17B10 (0.46) | GRIN2BRXRAGRIN1KMT2AALDH1A1 | |
| SCHEMBL22431611 | 0.78 | MAOB (0.36) | MAOBALDH1A1MAPT | |
| SCHEMBL900869 | 0.75 | ALDH1A1 (0.45) | GRIN2BRXRAGRIN1KMT2AALDH1A1 | |
| SCHEMBL29525099 | 0.75 | GRIN2B (0.41) | GRIN2BRXRAGRIN1KMT2AALDH1A1 | |
| SCHEMBL30349361 | 0.75 | GRIN2B (0.41) | GRIN2BRXRAGRIN1KMT2AALDH1A1 | |
| SCHEMBL14386474 | 0.75 | GRIN2B (0.41) | GRIN2BRXRAGRIN1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024220917-A1 | PRMT5 INHIBITORS AND USES THEREOF | GILEAD SCIENCES, INC. (US) | 2024-10-24 | — | — | WO | disclosed |
| EP-4313951-A1 | 1,3-SUBSTITUTED CYCLOBUTYL DERIVATIVES AND USES THEREOF | Novartis AG (CH) | 2024-02-07 | — | — | EP | disclosed |
| CN-117062804-A | 1, 3-substituted cyclobutyl derivatives and their use | 诺华股份有限公司 | 2023-11-14 | — | — | CN | disclosed |
| CN-111278818-B | BTK inhibitor compounds | 伊莱利利公司 | 2023-03-28 | — | — | CN | disclosed |
| WO-2022201097-A1 | 1,3-SUBSTITUTED CYCLOBUTYL DERIVATIVES AND USES THEREOF | NOVARTIS AG (CH) | 2022-09-29 | — | — | WO | disclosed |