Sugi Predict

Sugi Predict / Compounds / SCHEMBL7779435

SCHEMBL7779435

SCHEMBL7779435

Oc1ccc(OC(F)F)c(F)c1

nearest known ligand 0.38

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
▸ ESR1 P03372 6/20 0.38
▸ ESR2 Q92731 4/20 0.38
▸ KMT2A Q03164 2/20 0.37
▸ ALDH1A1 P00352 3/20 0.36
▸ MAPT P10636 2/20 0.36
▸ MEN1 O00255 1/20 0.36
▸ PPARG P37231 2/20 0.36
▸ PPARA Q07869 2/20 0.36
▸ MIF P14174 1/20 0.34
▸ PDE2A O00408 2/20 0.34
▸ PDE4A P27815 1/20 0.33
▸ PDE4B Q07343 1/20 0.33
▸ PDE4C Q08493 1/20 0.33
▸ PDE4D Q08499 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7916857 0.85 KIF11 (0.47) ESR1ESR2KMT2AMEN1
SCHEMBL29890232 0.83 GRIN2B (0.38) KMT2AALDH1A1MAPT
SCHEMBL983298 0.83 GRIN2B (0.38) KMT2AALDH1A1MAPT
SCHEMBL17175977 0.78 MEN1 (0.35) KMT2AALDH1A1MAPTMEN1PPARA
SCHEMBL16015525 0.78 ALDH1A1 (0.41) ESR1ESR2KMT2AALDH1A1MAPT
SCHEMBL366092 0.78 MAPT (0.48) ESR1KMT2AALDH1A1MAPTMEN1
SCHEMBL13825943 0.75 PPARG (0.33) KMT2AALDH1A1MAPTMEN1PPARG
SCHEMBL246292 0.75 SLC6A4 (0.47) ALDH1A1PPARGPPARA
SCHEMBL12474308 0.75 GRM2 (0.34) KMT2AALDH1A1MAPTMEN1PPARG
SCHEMBL11049484 0.75 KMT2A (0.40) KMT2AALDH1A1MAPTMEN1PPARG

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 25 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12435040-B2 1,3-substituted cyclobutyl derivatives and uses thereof BAUSCH + LOMB IRELAND LIMITED (IE) 2025-10-07 — — US disclosed
US-20240308965-A1 1,3-SUBSTITUTED CYCLOBUTYL DERIVATIVES AND USES THEREOF JPMORGAN CHASE BANK, N.A., AS SUCCESSOR AGENT 2024-09-19 — — US disclosed
EP-4313951-A1 1,3-SUBSTITUTED CYCLOBUTYL DERIVATIVES AND USES THEREOF Novartis AG (CH) 2024-02-07 — — EP disclosed
US-11845730-B2 1,3-substituted cyclobutyl derivatives and uses thereof CITIBANK, N.A., AS NOTES COLLATERAL AGENT 2023-12-19 — — US disclosed
CN-117062804-A 1, 3-substituted cyclobutyl derivatives and their use 诺华股份有限公司 2023-11-14 — — CN disclosed
US-20220324811-A1 1,3-SUBSTITUTED CYCLOBUTYL DERIVATIVES AND USES THEREOF CITIBANK, N.A., AS NOTES COLLATERAL AGENT 2022-10-13 — — US disclosed
WO-2022201097-A1 1,3-SUBSTITUTED CYCLOBUTYL DERIVATIVES AND USES THEREOF NOVARTIS AG (CH) 2022-09-29 — — WO disclosed
EP-3253755-B1 NOVEL CYCLOPROPABENZOFURANYL PYRIDOPYRAZINEDIONES PFIZER (US) 2020-08-26 — — EP disclosed
CN-107406445-B Cyclopropylbenzofuranyl pyridopyrazine diones 辉瑞公司 2019-12-24 — — CN disclosed
CN-107406445-A Cyclopropylbenzofuranyl pyridopyrazine diones 辉瑞公司 2017-11-28 — — CN disclosed
US-20170096428-A1 Novel Cyclopropabenzofuranyl Pyridopyrazinediones PFIZER INC. 2017-04-06 — — US disclosed
WO-2016125048-A1 NOVEL CYCLOPROPABENZOFURANYL PYRIDOPYRAZINEDIONES PFIZER INC. (US) 2016-08-11 — — WO disclosed
WO-2016125048-A1 NOVEL CYCLOPROPABENZOFURANYL PYRIDOPYRAZINEDIONES PFIZER INC. (US) 2016-08-11 — — WO disclosed
US-20160222007-A1 Novel Cyclopropabenzofuranyl Pyridopyrazinediones PFIZER (US) 2016-08-04 — — US disclosed
US-20160222007-A1 Novel Cyclopropabenzofuranyl Pyridopyrazinediones PFIZER (US) 2016-08-04 — — US disclosed
US-20160222007-A1 Novel Cyclopropabenzofuranyl Pyridopyrazinediones PFIZER (US) 2016-08-04 — — US disclosed
EP-0637623-B1 Cyclic hydrocarbon derivative and liquid crystal composition containing the same DAINIPPON INK & CHEMICALS (JP) 2001-10-04 — — EP disclosed
US-5536443-A DUTERIUM CONTAINING COMPOUNDS FOOR ELECTROOPTICAL APPARATUS DAINIPPON INK & CHEMICALS, INC. (JP) 1996-07-16 — — US disclosed
US-5474707-A Electrooptic display DAINIPPON INK AND CHEMICALS, INC. (JP) 1995-12-12 — — US disclosed
EP-0637623-A1 Cyclic hydrocarbon derivative and liquid crystal composition containing the same DAINIPPON INK AND CHEMICALS, INC. (JP) 1995-02-08 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11845730-B2 1,3-substituted cyclobutyl derivatives and uses thereof TRPV1, TRPV3, TRPV2 ESR1 3930/4885ESR2 2151/4885KMT2A 4773/4885
US-12435040-B2 1,3-substituted cyclobutyl derivatives and uses thereof TRPV1, TRPV3, TRPV2 ESR1 3930/4885ESR2 2151/4885KMT2A 4773/4885
US-20220324811-A1 1,3-SUBSTITUTED CYCLOBUTYL DERIVATIVES AND USES THEREOF TRPV1, TRPV3, TRPV2 ESR1 3930/4885ESR2 2151/4885KMT2A 4773/4885
US-20160222007-A1 Novel Cyclopropabenzofuranyl Pyridopyrazinediones CYP4B1, RXRB, ADRA2B ESR1 3136/4885ESR2 2184/4885KMT2A 3665/4885
US-20240308965-A1 1,3-SUBSTITUTED CYCLOBUTYL DERIVATIVES AND USES THEREOF TRPV1, TRPV3, TRPV2 ESR1 3930/4885ESR2 2151/4885KMT2A 4773/4885
US-20170096428-A1 Novel Cyclopropabenzofuranyl Pyridopyrazinediones CYP4B1, RXRB, ADRA2B ESR1 3136/4885ESR2 2184/4885KMT2A 3665/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.