Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 6/20 | 0.43 |
| ▸ | OPRL1 | P41146 | 6/20 | 0.43 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.40 |
| ▸ | SSTR4 | P31391 | 6/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | CNR2 | P34972 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | SSTR1 | P30872 | 4/20 | 0.36 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | KDM1A | O60341 | 1/20 | 0.35 |
| ▸ | MAOB | P27338 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2982776 | 0.90 | AQP3 (0.39) | OPRM1OPRL1SSTR4KMT2AL3MBTL1 | |
| SCHEMBL2987072 | 0.89 | SSTR4 (0.41) | SSTR4KMT2AL3MBTL1GAASSTR1 | |
| SCHEMBL2983449 | 0.89 | SSTR4 (0.44) | OPRM1OPRL1SSTR4KMT2ASSTR1 | |
| SCHEMBL2985320 | 0.88 | SSTR4 (0.43) | OPRL1SSTR4KMT2AALDH1A1MAOB | |
| SCHEMBL2987254 | 0.85 | SSTR4 (0.41) | SSTR4KMT2AALDH1A1GAASSTR1 | |
| SCHEMBL2985178 | 0.80 | SSTR4 (0.39) | OPRM1OPRL1SSTR4KMT2AL3MBTL1 | |
| SCHEMBL2991421 | 0.78 | OPRM1 (0.47) | OPRM1OPRL1OPRK1KMT2AALDH1A1 | |
| SCHEMBL4072703 | 0.78 | OPRM1 (0.40) | OPRM1OPRL1KMT2AL3MBTL1ALDH1A1 | |
| SCHEMBL2976479 | 0.77 | OPRM1 (0.52) | OPRM1OPRL1OPRK1KMT2AL3MBTL1 | |
| SCHEMBL206079 | 0.76 | OPRM1 (0.54) | OPRM1OPRL1OPRK1EPHX1EPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7786328-B2 | Cyclohexyl-1,4-diamine compounds | GRUENENTHAL GMBH (DE) | 2010-08-31 | — | — | US | claimed |
| US-20070281954-A1 | Cyclohexyl-1,4-diamine compounds | GRUENENTHAL GMBH (DE) | 2007-12-06 | — | — | US | claimed |
| US-7786328-B2 | Cyclohexyl-1,4-diamine compounds | GRUENENTHAL GMBH (DE) | 2010-08-31 | — | — | US | disclosed |
| US-20070281954-A1 | Cyclohexyl-1,4-diamine compounds | GRUENENTHAL GMBH (DE) | 2007-12-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070281954-A1 | Cyclohexyl-1,4-diamine compounds | DPYD, PKD1, AOC1 | OPRM1 1483/4885OPRL1 1292/4885OPRK1 376/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.