Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 14/20 | 0.54 |
| ▸ | KDM1A | O60341 | 1/20 | 0.44 |
| ▸ | TACR1 | P25103 | 1/20 | 0.44 |
| ▸ | ESR1 | P03372 | 1/20 | 0.43 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.43 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.39 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.39 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.39 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16401264 | 0.84 | RIPK1 (0.49) | RIPK1KDM1ATACR1SMYD3 | |
| SCHEMBL27077252 | 0.81 | RIPK1 (0.51) | RIPK1KDM1ATACR1ESR1ESR2 | |
| SCHEMBL29116152 | 0.81 | RIPK1 (0.48) | RIPK1KDM1AESR1ESR2CHRM3 | |
| SCHEMBL27077325 | 0.80 | KDM1A (0.56) | RIPK1KDM1ATACR1ESR1ESR2 | |
| SCHEMBL1576663 | 0.80 | RIPK1 (0.73) | RIPK1ESR1ESR2 | |
| SCHEMBL28171621 | 0.78 | RIPK1 (0.67) | RIPK1ESR1ESR2 | |
| SCHEMBL17964187 | 0.78 | RIPK1 (0.51) | RIPK1KDM1AESR1ESR2 | |
| SCHEMBL17782223 | 0.77 | RIPK1 (0.50) | RIPK1KDM1A | |
| SCHEMBL29893426 | 0.77 | RIPK1 (0.53) | RIPK1KDM1ATACR1ESR1ESR2 | |
| SCHEMBL29891698 | 0.77 | RIPK1 (0.46) | RIPK1KDM1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4313295-A1 | PHARMACEUTICAL COMPOUNDS AS INHIBITORS OF UBIQUITIN SPECIFIC PROTEASE 19 (USP19) | Almac Discovery Limited (GB) | 2024-02-07 | — | — | EP | disclosed |
| WO-2022200523-A9 | PHARMACEUTICAL COMPOUNDS AS INHIBITORS OF UBIQUITIN SPECIFIC PROTEASE 19 (USP19) | ALMAC DISCOVERY LIMITED (GB) | 2023-02-16 | — | — | WO | disclosed |
| WO-2022200523-A1 | PHARMACEUTICALS COMPOUNDS AS INHIBITORS OF UBIQUITIN SPECIFIC PROTEASE 19 (USP19) | ALMAC DISCOVERY LIMITED (GB) | 2022-09-29 | — | — | WO | disclosed |