Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 7/20 | 0.49 |
| ▸ | KDM1A | O60341 | 1/20 | 0.41 |
| ▸ | MAOA | P21397 | 1/20 | 0.41 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | TACR1 | P25103 | 1/20 | 0.40 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.39 |
| ▸ | BACE1 | P56817 | 1/20 | 0.39 |
| ▸ | CFB | P00751 | 1/20 | 0.39 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.38 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.38 |
| ▸ | PRMT5 | O14744 | 2/20 | 0.38 |
| ▸ | WDR77 | Q9BQA1 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20449214 | 0.85 | RIPK1 (0.50) | RIPK1POLBHSD11B1BACE1HSP90AA1 | |
| SCHEMBL20449170 | 0.85 | RIPK1 (0.50) | RIPK1POLBHSD11B1BACE1HSP90AA1 | |
| SCHEMBL29116156 | 0.84 | RIPK1 (0.49) | RIPK1MAOATACR1 | |
| SCHEMBL29891706 | 0.84 | RIPK1 (0.54) | RIPK1KDM1ASMYD3TACR1 | |
| SCHEMBL29891698 | 0.83 | RIPK1 (0.46) | RIPK1KDM1AMAOAPOLBHSD11B1 | |
| SCHEMBL17026995 | 0.83 | RIPK1 (0.67) | RIPK1POLBHSD11B1HSP90AA1HSP90AB1 | |
| SCHEMBL16401399 | 0.82 | RIPK1 (0.50) | RIPK1POLBHSD11B1BACE1CFB | |
| SCHEMBL30668564 | 0.81 | PRMT5 (0.54) | RIPK1POLBHSD11B1BACE1PRMT5 | |
| SCHEMBL580929 | 0.81 | AKR1C3 (0.51) | RIPK1POLB | |
| SCHEMBL17782223 | 0.81 | RIPK1 (0.50) | RIPK1KDM1AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104955824-B | It is used as the aminopyrimidine compounds of the inhibitor of the EGFR mutant containing T790M | 豪夫迈·罗氏有限公司 | 2017-09-22 | — | — | CN | disclosed |
| EP-3022192-A1 | PIPERIDINYL INDOLE DERIVATIVES AND THEIR USE AS COMPLEMENT FACTOR B INHIBITORS | Novartis AG (CH) | 2016-05-25 | — | — | EP | disclosed |
| WO-2015009616-A1 | PIPERIDINYL INDOLE DERIVATIVES AND THEIR USE AS COMPLEMENT FACTOR B INHIBITORS | NOVARTIS AG (CH) | 2015-01-22 | — | — | WO | disclosed |