Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 2/20 | 0.44 |
| ▸ | TLR2 | O60603 | 1/20 | 0.43 |
| ▸ | TLR1 | Q15399 | 1/20 | 0.43 |
| ▸ | NAMPT | P43490 | 7/20 | 0.42 |
| ▸ | CYP1A1 | P04798 | 2/20 | 0.41 |
| ▸ | CYP1B1 | Q16678 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | ERAP2 | Q6P179 | 1/20 | 0.39 |
| ▸ | ERAP1 | Q9NZ08 | 1/20 | 0.39 |
| ▸ | KDR | P35968 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | NCS1 | P62166 | 1/20 | 0.37 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29892962 | 0.90 | TLR2 (0.45) | NOTUMTLR2TLR1NAMPTKDM4E | |
| SCHEMBL29892708 | 0.85 | SMN1; SMN2 (0.44) | TLR2TLR1NAMPTKDM4EALDH1A1 | |
| SCHEMBL29893417 | 0.83 | LMNA (0.47) | NOTUMTLR2TLR1NAMPTKDM4E | |
| SCHEMBL27077390 | 0.80 | KDM4E (0.43) | NAMPTKDM4EERAP2ERAP1MRGPRX4 | |
| SCHEMBL27077449 | 0.80 | TLR2 (0.54) | TLR2TLR1 | |
| SCHEMBL29892946 | 0.79 | MRGPRX4 (0.42) | NOTUMCYP1A1CYP1B1KDM4EALDH1A1 | |
| SCHEMBL27077496 | 0.77 | KDM4E (0.46) | NAMPTKDM4EALDH1A1LMNA | |
| SCHEMBL29893923 | 0.77 | KDM4E (0.46) | NAMPTKDM4EALDH1A1LMNA | |
| SCHEMBL31212371 | 0.76 | NPC1 (0.47) | NAMPTKDM4EALDH1A1LMNA | |
| SCHEMBL25983146 | 0.76 | NPC1 (0.47) | NAMPTKDM4EALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4313308-A1 | TEAD INHIBITORS AND USES THEREOF | Cedilla Therapeutics, Inc. (US) | 2024-02-07 | — | — | EP | disclosed |
| WO-2022204452-A1 | TEAD INHIBITORS AND USES THEREOF | CEDILLA THERAPEUTICS, INC. (US) | 2022-09-29 | — | — | WO | disclosed |