Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | NAMPT | P43490 | 2/20 | 0.42 |
| ▸ | TLR2 | O60603 | 1/20 | 0.42 |
| ▸ | TLR1 | Q15399 | 1/20 | 0.42 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.41 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.40 |
| ▸ | EGFR | P00533 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | DHODH | Q02127 | 2/20 | 0.39 |
| ▸ | NCS1 | P62166 | 1/20 | 0.39 |
| ▸ | DGAT2 | Q96PD7 | 1/20 | 0.39 |
| ▸ | BACE1 | P56817 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27077496 | 0.92 | KDM4E (0.46) | SMN1; SMN2ALDH1A1KDM4EHPGDLMNA | |
| SCHEMBL29893923 | 0.92 | KDM4E (0.46) | SMN1; SMN2ALDH1A1KDM4EHPGDLMNA | |
| SCHEMBL29892962 | 0.87 | TLR2 (0.45) | ALDH1A1KDM4ELMNANAMPTTLR2 | |
| SCHEMBL29893144 | 0.85 | NOTUM (0.44) | ALDH1A1KDM4ELMNANAMPTTLR2 | |
| SCHEMBL25981004 | 0.82 | ALDH1A1 (0.64) | SMN1; SMN2ALDH1A1KDM4EHPGDLMNA | |
| SCHEMBL27077390 | 0.80 | KDM4E (0.43) | KDM4ENAMPTMEN1KMT2ATDP1 | |
| SCHEMBL29893417 | 0.79 | LMNA (0.47) | ALDH1A1KDM4ELMNANAMPTTLR2 | |
| SCHEMBL31212371 | 0.78 | NPC1 (0.47) | SMN1; SMN2ALDH1A1KDM4EHPGDLMNA | |
| SCHEMBL25983146 | 0.78 | NPC1 (0.47) | SMN1; SMN2ALDH1A1KDM4EHPGDLMNA | |
| SCHEMBL27077449 | 0.78 | TLR2 (0.54) | TLR2TLR1RAF1BRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4313308-A1 | TEAD INHIBITORS AND USES THEREOF | Cedilla Therapeutics, Inc. (US) | 2024-02-07 | — | — | EP | disclosed |
| WO-2022204452-A1 | TEAD INHIBITORS AND USES THEREOF | CEDILLA THERAPEUTICS, INC. (US) | 2022-09-29 | — | — | WO | disclosed |