Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.42 |
| ▸ | NAMPT | P43490 | 1/20 | 0.41 |
| ▸ | DHODH | Q02127 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | PTGFR | P43088 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | IP6K1 | Q92551 | 1/20 | 0.40 |
| ▸ | IP6K3 | Q96PC2 | 1/20 | 0.40 |
| ▸ | IP6K2 | Q9UHH9 | 1/20 | 0.40 |
| ▸ | BACE1 | P56817 | 1/20 | 0.40 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.39 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.39 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27077496 | 1.00 | KDM4E (0.46) | KDM4ESMN1; SMN2ALDH1A1LMNAHPGD | |
| SCHEMBL29892708 | 0.92 | SMN1; SMN2 (0.44) | KDM4ESMN1; SMN2ALDH1A1LMNAHPGD | |
| SCHEMBL27077390 | 0.88 | KDM4E (0.43) | KDM4ENAMPTMEN1POLBKMT2A | |
| SCHEMBL29892985 | 0.84 | KDM4E (0.49) | KDM4ESMN1; SMN2ALDH1A1LMNAHPGD | |
| SCHEMBL25981084 | 0.81 | SMN1; SMN2 (0.67) | KDM4ESMN1; SMN2ALDH1A1LMNAHPGD | |
| SCHEMBL29893160 | 0.79 | TDO2 (0.42) | KDM4ESMN1; SMN2ALDH1A1LMNADHODH | |
| SCHEMBL29893182 | 0.79 | ADH5 (0.43) | KDM4EALDH1A1CSNK2A1 | |
| SCHEMBL27077393 | 0.79 | ADH5 (0.43) | KDM4EALDH1A1CSNK2A1 | |
| SCHEMBL31212293 | 0.79 | CSNK2A2 (0.52) | KDM4ESMN1; SMN2ALDH1A1LMNAHPGD | |
| SCHEMBL25983147 | 0.79 | CSNK2A2 (0.52) | KDM4ESMN1; SMN2ALDH1A1LMNAHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4313308-A1 | TEAD INHIBITORS AND USES THEREOF | Cedilla Therapeutics, Inc. (US) | 2024-02-07 | — | — | EP | disclosed |
| WO-2022204452-A1 | TEAD INHIBITORS AND USES THEREOF | CEDILLA THERAPEUTICS, INC. (US) | 2022-09-29 | — | — | WO | disclosed |