Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 2/20 | 0.50 |
| ▸ | NR4A2 | P43354 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.45 |
| ▸ | GAA | P10253 | 2/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | PADI4 | Q9UM07 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KIF11 | P52732 | 1/20 | 0.44 |
| ▸ | TNKS | O95271 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | BRD4 | O60885 | 1/20 | 0.42 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15721658 | 0.85 | PARP1 (0.46) | PARP1CYP1A2 | |
| SCHEMBL14647112 | 0.83 | PARP1 (0.46) | PARP1KDM4ECYP1A2 | |
| SCHEMBL15703252 | 0.80 | BRD4 (0.46) | PARP1ALDH1A1MAPTBRD4 | |
| SCHEMBL14647126 | 0.78 | ALDH1A1 (0.50) | PARP1ALDH1A1KDM4EGAAHTT | |
| SCHEMBL14647128 | 0.77 | PARP1 (0.51) | PARP1ALDH1A1GAAKMT2AMEN1 | |
| SCHEMBL14647212 | 0.77 | PARP1 (0.61) | PARP1KMT2AMEN1TNKS | |
| SCHEMBL14647263 | 0.77 | PARP1 (0.52) | PARP1ALDH1A1KDM4EHTTKMT2A | |
| SCHEMBL14647181 | 0.75 | PARP1 (0.56) | PARP1KMT2A | |
| SCHEMBL14647123 | 0.75 | PARP1 (0.49) | PARP1ALDH1A1KDM4EHTTKMT2A | |
| SCHEMBL12822200 | 0.74 | MAT2A (0.57) | PARP1NR4A2ALDH1A1GAAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4313308-A1 | TEAD INHIBITORS AND USES THEREOF | Cedilla Therapeutics, Inc. (US) | 2024-02-07 | — | — | EP | disclosed |
| WO-2022204452-A1 | TEAD INHIBITORS AND USES THEREOF | CEDILLA THERAPEUTICS, INC. (US) | 2022-09-29 | — | — | WO | disclosed |