Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.57 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.44 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.44 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
| ▸ | KCNH3 | Q9ULD8 | 5/20 | 0.39 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.38 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.36 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | MMP3 | P08254 | 1/20 | 0.36 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.36 |
| ▸ | IDO1 | P14902 | 1/20 | 0.33 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL897832 | 1.00 | LOXL2 (0.57) | LOXL2KCNQ2CYP3A4ALOX15TSHR | |
| SCHEMBL3676475 | 0.79 | ENPP2 (0.40) | LOXL2ENPP2CYP11B1CYP11B2KDM4E | |
| SCHEMBL13183449 | 0.76 | ENPP2 (0.38) | LOXL2ENPP2CYP11B1CYP11B2KDM4E | |
| SCHEMBL1670797 | 0.76 | ENPP2 (0.38) | LOXL2ENPP2KDM4ETDP1MMP3 | |
| SCHEMBL25673666 | 0.76 | MYC (0.39) | ENPP2CYP11B1CYP11B2KDM4ETDP1 | |
| SCHEMBL30834457 | 0.76 | ENPP2 (0.38) | LOXL2ENPP2KDM4ETDP1MMP3 | |
| SCHEMBL29841095 | 0.76 | GRM5 (0.46) | KCNQ2CYP3A4ENPP2KDM4ETDP1 | |
| SCHEMBL9280722 | 0.76 | RECQL (0.57) | LOXL2ENPP2CYP11B1CYP11B2KDM4E | |
| SCHEMBL1925278 | 0.76 | GRM5 (0.46) | KCNQ2CYP3A4ENPP2KDM4ETDP1 | |
| SCHEMBL7375163 | 0.76 | NOS3 (0.57) | LOXL2KCNH3ENPP2KDM4ETDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4577536-A1 | PYRAZOLYLSULFONAMIDE COMPOUNDS AND THEIR USE IN THERAPY | Hotspot Therapeutics, Inc. (US) | 2025-07-02 | — | — | EP | disclosed |
| WO-2024044730-A1 | PYRAZOLYLSULFONAMIDE COMPOUNDS AND THEIR USE IN THERAPY | HOTSPOT THERAPEUTICS, INC. (US) | 2024-02-29 | — | — | WO | disclosed |
| CN-115215862-A | Pyrimidone compounds and uses thereof | 武汉人福创新药物研发中心有限公司 | 2022-10-21 | — | — | CN | disclosed |