SCHEMBL298948

SCHEMBL298948

CCc1cc(C(F)(C(F)(F)F)C(F)(F)C(F)(F)F)cc(C)c1N

nearest known ligand 0.41

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
HTT P42858 2/20 0.41
ALDH1A1 P00352 1/20 0.41
MAPT P10636 1/20 0.41
POLB P06746 2/20 0.33
NOS3 P29474 1/20 0.33
NOS1 P29475 1/20 0.33
NOS2 P35228 1/20 0.33
KIF11 P52732 1/20 0.32
AR P10275 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1274977 0.91 HTT (0.47) HTTALDH1A1MAPTPOLBNOS3
SCHEMBL13516211 0.87 HTT (0.41) HTTALDH1A1MAPTPOLBNOS3
SCHEMBL18724461 0.87 HTT (0.41) HTTALDH1A1MAPTPOLBNOS3
SCHEMBL288953 0.84 POLB (0.46) ALDH1A1POLB
SCHEMBL1275830 0.82 HTT (0.42) HTTALDH1A1MAPTPOLBNOS3
SCHEMBL298436 0.81 PGR (0.39) HTTALDH1A1MAPTPOLBNOS3
SCHEMBL23557907 0.80 ALDH1A1 (0.46) HTTALDH1A1MAPTPOLBNOS3
SCHEMBL1819523 0.78 PGR (0.45) HTTALDH1A1MAPTNOS3NOS1
SCHEMBL9894395 0.77 ALDH1A1 (0.36) HTTALDH1A1MAPT
SCHEMBL19240525 0.76 POLB (0.35) ALDH1A1POLBAR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 41 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-106242998-B Use of 4-cyano-3-benzoylamino-N-phenyl-benzamides in pesticides 先正达参股股份有限公司 2021-11-05 CN disclosed
EP-3366675-A1 INSECTICIDAL 2-METHOXYBENZAMIDE DERIVATIVES SYNGENTA PARTICIPATIONS AG (CH) 2018-08-29 EP disclosed
EP-3339286-A1 INSECTICIDAL COMPOUNDS SYNGENTA PARTICIPATIONS AG (CH) 2018-06-27 EP disclosed
EP-2763966-B1 INSECTICIDAL 2-METHOXYBENZAMIDE DERIVATIVES SYNGENTA PARTICIPATIONS AG (CH) 2018-04-04 EP disclosed
EP-2427426-B1 INSECTICIDAL COMPOUNDS SYNGENTA PARTICIPATIONS AG (CH) 2018-02-07 EP disclosed
CN-106749129-A Pesticidal compound 先正达参股股份有限公司 2017-05-31 CN disclosed
CN-104011024-B Insecticidal 2-methoxybenzamide derivatives 先正达参股股份有限公司 2017-05-17 CN disclosed
EP-2456759-B1 PESTICIDAL CARBOXAMIDES BAYER CROPSCIENCE AG (DE) 2017-04-19 EP disclosed
EP-3153497-A2 PESTICIDAL CARBOXAMIDES Bayer Cropscience AG (DE) 2017-04-12 EP disclosed
CN-102414170-B Insecticidal compounds 先正达参股股份有限公司 2017-03-22 CN disclosed
US-20120122975-A1 4-CYANO-3-BENZOYLAMINO-N-PHENYL-BENZAMIDES FOR USE IN PEST CONTROL SYNGENTA CROP PROTECTION LLC (US) 2012-05-17 US disclosed
US-20120122975-A1 4-CYANO-3-BENZOYLAMINO-N-PHENYL-BENZAMIDES FOR USE IN PEST CONTROL SYNGENTA CROP PROTECTION LLC (US) 2012-05-17 US disclosed
US-20120122975-A1 4-CYANO-3-BENZOYLAMINO-N-PHENYL-BENZAMIDES FOR USE IN PEST CONTROL SYNGENTA CROP PROTECTION LLC (US) 2012-05-17 US disclosed
EP-2427426-A1 INSECTICIDAL COMPOUNDS Syngenta Participations AG (CH) 2012-03-14 EP disclosed
EP-2427427-A1 4 -CYANO- 3 -BENZOYLAMINO-N- PHENYL-BENZAMIDES FOR USE IN PEST CONTROL Syngenta Participations AG (CH) 2012-03-14 EP disclosed
WO-2011018170-A2 PESTICIDAL CARBOXAMIDES BAYER CROPSCIENCE AG (DE) 2011-02-17 WO disclosed
WO-2010127928-A1 INSECTICIDAL COMPOUNDS SYNGENTA PARTICIPATIONS AG (CH) 2010-11-11 WO disclosed
WO-2010127928-A1 INSECTICIDAL COMPOUNDS SYNGENTA PARTICIPATIONS AG (CH) 2010-11-11 WO disclosed
WO-2010127926-A1 4 -CYANO- 3 -BENZOYLAMINO-N- PHENYL-BENZAMIDES FOR USE IN PEST CONTROL SYNGENTA PARTICIPATIONS AG (CH) 2010-11-11 WO disclosed
WO-2010127926-A1 4 -CYANO- 3 -BENZOYLAMINO-N- PHENYL-BENZAMIDES FOR USE IN PEST CONTROL SYNGENTA PARTICIPATIONS AG (CH) 2010-11-11 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120122975-A1 4-CYANO-3-BENZOYLAMINO-N-PHENYL-BENZAMIDES FOR USE IN PEST CONTROL NISCH, AADAC, ACHE HTT 3238/4885ALDH1A1 989/4885MAPT 3060/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.