Sugi Predict

Sugi Predict / Compounds / SCHEMBL298966

SCHEMBL298966

SCHEMBL298966

C=Cc1n[nH]c2ccccc12

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ KDM4E B2RXH2 4/20 0.52
▸ GAA P10253 2/20 0.52
▸ PDPK1 O15530 2/20 0.52
▸ CYP3A4 P08684 1/20 0.52
▸ IDO1 P14902 3/20 0.48
▸ ALDH1A1 P00352 2/20 0.48
▸ TTK P33981 2/20 0.48
▸ MAPK10 P53779 2/20 0.48
▸ ALPL P05186 1/20 0.48
▸ HPGD P15428 1/20 0.48
▸ CYP1A2 P05177 1/20 0.44
▸ LRRK2 Q5S007 3/20 0.42
▸ NPC1 O15118 1/20 0.42
▸ TP53 P04637 1/20 0.42
▸ RAB9A P51151 1/20 0.42
▸ PIM1 P11309 1/20 0.41
▸ AURKA O14965 3/20 0.40
▸ FGFR1 P11362 2/20 0.40
▸ FLT1 P17948 2/20 0.40
▸ ITK Q08881 2/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31190846 1.00 KDM4E (0.52) KDM4EGAAPDPK1CYP3A4IDO1
SCHEMBL2880877 0.84 KDM4E (0.48) KDM4EGAAPDPK1CYP3A4IDO1
SCHEMBL18844727 0.81 CHEK1 (0.53) PDPK1TTKMAPK10LRRK2AURKA
SCHEMBL7329986 0.79 KDM4E (0.52) KDM4EGAAPDPK1CYP3A4IDO1
SCHEMBL7331545 0.79 KDM4E (0.52) KDM4EGAAPDPK1CYP3A4IDO1
SCHEMBL5693192 0.79 KDM4E (0.52) KDM4EGAAPDPK1CYP3A4IDO1
SCHEMBL7331167 0.79 KDM4E (0.57) KDM4EGAAPDPK1CYP3A4IDO1
SCHEMBL14412480 0.79 KDM4E (0.52) KDM4EGAAPDPK1CYP3A4IDO1
SCHEMBL29643994 0.79 KDM4E (0.52) KDM4EGAAPDPK1CYP3A4IDO1
SCHEMBL730639 0.79 KDM4E (0.52) KDM4EGAAPDPK1CYP3A4IDO1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 103 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-116554148-B Vinyl indazole deuterated FGFR inhibitor drug and application thereof 药康众拓(北京)医药科技有限公司 2025-01-28 — — CN claimed
CN-116554148-A Vinyl indazole deuterated FGFR inhibitor drug and application thereof 药康众拓(北京)医药科技有限公司 2023-08-08 — — CN claimed
CN-113694903-B Phosphorus-containing polymer hydrogel and preparation method and application thereof 重庆市化工研究院有限公司 2022-06-24 — — CN claimed
CN-113694903-A Phosphorus-containing polymer hydrogel and preparation method and application thereof 重庆市化工研究院有限公司 2021-11-26 — — CN claimed
EP-2556070-B1 SYNTHESIS OF CHIRAL 2-(1H-INDAZOL-6-YL)-SPIRO[CYCLOPROPANE-1,3'- INDOLIN]-2'-ONES UNIV HEALTH NETWORK (CA) 2017-06-07 — — EP claimed
US-9579327-B2 Synthesis of chiral 2-(1H-indazol-6-yl)-spiro[cyclopropane-1,3′-indolin]-2′-ones UNIVERSITY HEALTH NETWORK (CA) 2017-02-28 — — US claimed
US-20150133677-A1 SYNTHESIS OF CHIRAL 2-(1H-INDAZOL-6-YL)-SPIRO[CYCLOPROPANE-1,3'-INDOLIN]-2'-ONES UNIVERSITY HEALTH NETWORK (CA) 2015-05-14 — — US claimed
US-20130096301-A1 KINASE INHIBITORS AND METHOD OF TREATING CANCER WITH SAME UNIVERSITY HEALTH NETWORK (CA) 2013-04-18 — — US claimed
EP-2556070-A1 SYNTHESIS OF CHIRAL 2-(1H-INDAZOL-6-YL)-SPIRO[CYCLOPROPANE-1,3'- INDOLIN]-2'-ONES University Health Network (CA) 2013-02-13 — — EP claimed
WO-2011123947-A1 SYNTHESIS OF CHIRAL 2-(1H-INDAZOL-6-YL)-SPIRO[CYCLOPROPANE-1,3'- INDOLIN]-2'-ONES UNIVERSITY HEALTH NETWORK (CA) 2011-10-13 — — WO claimed
US-20060281789-A1 Protein kinase inhibitors KYOWA HAKKO KOGYO CO., LTD (JP) 2006-12-14 — — US claimed
EP-1650194-A1 PROTEIN KINASE INHIBITOR KYOWA HAKKO KOGYO CO., LTD. (JP) 2006-04-26 — — EP claimed
JP-7082321-A — — None — — JP disclosed
EP-4735425-A1 COMPOUNDS Psylo Pty Ltd (AU) 2026-05-06 — — EP disclosed
US-12441707-B2 Indazole compounds TYRA BIOSCIENCES, INC. (US) 2025-10-14 — — US disclosed
CN-116554148-B Vinyl indazole deuterated FGFR inhibitor drug and application thereof 药康众拓(北京)医药科技有限公司 2025-01-28 — — CN disclosed
US-20030207868-A1 Substituted 2-methyl-benzimidazole respiratory syncytial virus antiviral agents BRISTOL-MYERS SQUIBB COMPANY 2003-11-06 — — US disclosed
WO-2003053344-A2 SUBSTITUTED 2-METHYL-BENZIMIDAZOLE RESPIRATORY SYNCYTIAL VIRUS ANTIVIRAL AGENTS BRISTOL-MYERS SQUIBB COMPANY (US) 2003-07-03 — — WO disclosed
JP-H0782321-A AZAINDOLE POLYMER DERIVATIVE AND BACTERICIDE CONTAINING THE SAME AS ACTIVE INGREDIENT SUMITOMO CHEM CO LTD 1995-03-28 — — JP disclosed
US-4966825-A Containing an ethylenic copolymer and dielectric FUJI PHOTO FILM CO., LTD. (JP) 1990-10-30 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20150133677-A1 SYNTHESIS OF CHIRAL 2-(1H-INDAZOL-6-YL)-SPIRO[CYCLOPROPANE-1,3'-INDOLIN]-2'-ONES REN, IDO1, PKD1 KDM4E 4273/4885GAA 4005/4885PDPK1 654/4885
US-20060281789-A1 Protein kinase inhibitors MAP3K20, MAP3K1, MAP3K19 KDM4E 1355/4885GAA 3649/4885PDPK1 176/4885
US-20130096301-A1 KINASE INHIBITORS AND METHOD OF TREATING CANCER WITH SAME MAP3K19, MAP3K1, MAP3K20 KDM4E 979/4885GAA 2819/4885PDPK1 55/4885
US-20030207868-A1 Substituted 2-methyl-benzimidazole respiratory syncytial virus antiviral agents MAVS, ZC3HAV1, EIF2AK2 KDM4E 335/4885GAA 1396/4885PDPK1 3709/4885
US-12441707-B2 Indazole compounds BRCA1, IDH2, TP53 KDM4E 3704/4885GAA 411/4885PDPK1 557/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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