Known targets — ChEMBL curated mechanism
FGFR1FGFR2FGFR3FGFR4FLT1FLT4KDRPDGFRAPDGFRB
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | BBOX1 | O75936 | 3/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | CA1 | P00915 | 1/20 | 0.31 |
| ▸ | GMNN | O75496 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
| ▸ | THPO | P40225 | 1/20 | 0.30 |
| ▸ | HBB | P68871 | 1/20 | 0.30 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2986611 | 0.92 | — | — | |
| SCHEMBL19809549 | 0.84 | BBOX1 (0.38) | KDM4ECYP3A4BBOX1MAPTALOX15 | |
| SCHEMBL1552464 | 0.84 | BBOX1 (0.38) | KDM4ECYP3A4BBOX1MAPTALOX15 | |
| SCHEMBL2367141 | 0.84 | BBOX1 (0.38) | KDM4ECYP3A4BBOX1MAPTALOX15 | |
| SCHEMBL20533678 | 0.84 | — | — | |
| SCHEMBL9001604 | 0.84 | BBOX1 (0.38) | KDM4ECYP3A4BBOX1MAPTALOX15 | |
| SCHEMBL20533681 | 0.84 | BBOX1 (0.38) | KDM4ECYP3A4BBOX1MAPTALOX15 | |
| SCHEMBL22581623 | 0.84 | BBOX1 (0.38) | KDM4ECYP3A4BBOX1MAPTALOX15 | |
| SCHEMBL20533647 | 0.84 | BBOX1 (0.38) | KDM4ECYP3A4BBOX1MAPTALOX15 | |
| SCHEMBL20583852 | 0.84 | BBOX1 (0.38) | KDM4ECYP3A4BBOX1MAPTALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10328425-B2 | Functionalized main chain polymers | HAERING THOMAS (DE) | 2019-06-25 | — | — | US | disclosed |
| US-20170266652-A1 | FUNCTIONALIZED MAIN CHAIN POLYMERS | HÄRING THOMAS (DE) | 2017-09-21 | — | — | US | disclosed |
| US-20170095809-A1 | FUNCTIONALIZED MAIN CHAIN POLYMERS | HÄRING THOMAS (DE) | 2017-04-06 | — | — | US | disclosed |
| US-20140155502-A1 | FUNCTIONALIZED MAIN CHAIN POLYMERS | Häring, Thomas (DE) | 2014-06-05 | — | — | US | disclosed |
| US-8710175-B2 | Functionalized main chain polymers | Häring, Thomas (DE) | 2014-04-29 | — | — | US | disclosed |
| US-20100081783-A1 | Functionalized Main Chain Polymers | HARING THOMAS | 2010-04-01 | — | — | US | disclosed |
| US-7615599-B2 | Noncrosslinked, covalently crosslinked and/or ionically crosslinked polymer which can be used in direct methanol fuel cells; sulfonated polyetherketones and sulfonated polysulfones; acid doped polymer has high mechanical stability and a low permeability for hydrogen, oxygen and methanol | HAERING THOMAS | 2009-11-10 | — | — | US | disclosed |
| US-20070208153-A1 | Functionalized Main Chain Polymers | HARING THOMAS | 2007-09-06 | — | — | US | disclosed |
| US-7196151-B2 | Functionalized main chain polymers | HAERING THOMAS | 2007-03-27 | — | — | US | disclosed |
| US-20050124769-A1 | Noncrosslinked, covalently crosslinked and/or ionically crosslinked polymer which can be used in direct methanol fuel cells; acid doped polymer has high mechanical stability and a low permeability for hydrogen, oxygen and methanol | HARING THOMAS (DE) | 2005-06-09 | — | — | US | disclosed |