Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 17/20 | 0.78 |
| ▸ | DRD1 | P21728 | 9/20 | 0.78 |
| ▸ | CHRM1 | P11229 | 4/20 | 0.78 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.78 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.78 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.78 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.78 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.78 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.78 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.78 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.78 |
| ▸ | MTOR | P42345 | 1/20 | 0.78 |
| ▸ | DRD3 | P35462 | 3/20 | 0.76 |
| ▸ | DRD4 | P21917 | 3/20 | 0.76 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.76 |
| ▸ | DRD5 | P21918 | 2/20 | 0.76 |
| ▸ | HRH1 | P35367 | 2/20 | 0.76 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.76 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.76 |
| ▸ | MEN1 | O00255 | 1/20 | 0.76 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20887469 | 0.92 | DRD2 (0.88) | DRD2DRD1CHRM1CYP1A2CHRM2 | |
| SCHEMBL3411880 | 0.89 | DRD2 (0.80) | DRD2DRD1CHRM1CYP1A2CHRM2 | |
| N-Desmethylclozapine SCHEMBL29365906 | 0.88 | DRD2 (1.00) | DRD2DRD1CHRM1CYP1A2CHRM2 | |
| N-Desmethylclozapine SCHEMBL781423 | 0.88 | DRD2 (1.00) | DRD2DRD1CHRM1CYP1A2CHRM2 | |
| N-Desmethylclozapine SCHEMBL30416482 | 0.88 | DRD2 (1.00) | DRD2DRD1CHRM1CYP1A2CHRM2 | |
| N-Desmethylclozapine SCHEMBL29360816 | 0.88 | DRD2 (1.00) | DRD2DRD1CHRM1CYP1A2CHRM2 | |
| Clozapine SCHEMBL8397 | 0.86 | DRD2 (1.00) | DRD2DRD1CHRM1CYP1A2CHRM2 | |
| Clozapine SCHEMBL20876213 | 0.86 | DRD2 (1.00) | DRD2DRD1CHRM1CYP1A2CHRM2 | |
| Clozapine SCHEMBL29590817 | 0.86 | DRD2 (1.00) | DRD2DRD1CHRM1CYP1A2CHRM2 | |
| Clozapine SCHEMBL5501558 | 0.86 | DRD2 (1.00) | DRD2DRD1CHRM1CYP1A2CHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100129473-A1 | AMINO SUBSTITUTED DIARYL[a,d]CYCLOHEPTENE ANALOGS AS MUSCARINIC AGONISTS AND METHODS OF TREATMENT OF NEUROPSYCHIATRIC DISORDERS | ACADIA PHARMACEUTICALS, INC. (US) | 2010-05-27 | — | — | US | disclosed |
| US-20090239840-A1 | AMINO SUBSTITUTED DIARYL[a,d]CYCLOHEPTENE ANALOGS AS MUSCARINIC AGONISTS AND METHODS OF TREATMENT OF NEUROPSYCHIATRIC DISORDERS | ACADIA PHARMACEUTICALS, INC. (US) | 2009-09-24 | — | — | US | disclosed |
| US-7550454-B2 | Amino substituted diaryl[a,d]cycloheptene analogs as muscarinic agonists and methods of treatment of neuropsychiatric disorders | ACADIA PHARMACEUTICALS, INC. (US) | 2009-06-23 | — | — | US | disclosed |
| US-7491715-B2 | Amino substituted diaryl[a,d]cycloheptene analogs as muscarinic agonists and methods of treatment of neuropsychiatric disorders | ACADIA PHARMACEUTICALS, INC. (US) | 2009-02-17 | — | — | US | disclosed |
| US-20060194784-A1 | Amino substituted diaryl[a,d]cycloheptene analogs as muscarinic agonists and methods of treatment of neuropsychiatric disorders | EK FREDRIK | 2006-08-31 | — | — | US | disclosed |
| US-20050192268-A1 | Amino substituted diaryl[a,d]cycloheptene analogs as muscarinic agonists and methods of treatment of neuropsychiatric disorders | ACADIA PHARMACEUTICALS INC. | 2005-09-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100129473-A1 | AMINO SUBSTITUTED DIARYL[a,d]CYCLOHEPTENE ANALOGS AS MUSCARINIC AGONISTS AND METHODS OF TREATMENT OF NEUROPSYCHIATRIC DISORDERS | CHRM4, CHRM5, CHRM1 | DRD2 29/4885DRD1 48/4885CHRM1 3/4885 |
| US-20060194784-A1 | Amino substituted diaryl[a,d]cycloheptene analogs as muscarinic agonists and methods of treatment of neuropsychiatric disorders | CHRM4, CHRM5, CHRNA10 | DRD2 31/4885DRD1 58/4885CHRM1 7/4885 |
| US-20090239840-A1 | AMINO SUBSTITUTED DIARYL[a,d]CYCLOHEPTENE ANALOGS AS MUSCARINIC AGONISTS AND METHODS OF TREATMENT OF NEUROPSYCHIATRIC DISORDERS | CHRM4, CHRM5, CHRNA10 | DRD2 31/4885DRD1 58/4885CHRM1 7/4885 |
| US-20050192268-A1 | Amino substituted diaryl[a,d]cycloheptene analogs as muscarinic agonists and methods of treatment of neuropsychiatric disorders | CHRM4, CHRM5, CHRNA10 | DRD2 31/4885DRD1 58/4885CHRM1 7/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.