Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NLRP3 | Q96P20 | 8/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.36 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29899355 | 0.83 | ALDH1A1 (0.50) | NLRP3ALDH1A1GAAHSP90AA1 | |
| SCHEMBL26981859 | 0.83 | LMNA (0.42) | NLRP3LMNAALDH1A1TDP1L3MBTL1 | |
| SCHEMBL26730529 | 0.83 | LMNA (0.42) | NLRP3LMNAALDH1A1TDP1L3MBTL1 | |
| SCHEMBL26982604 | 0.77 | NLRP3 (0.62) | NLRP3LMNAALDH1A1 | |
| SCHEMBL24376356 | 0.74 | MAPK8 (0.37) | LMNAALDH1A1TDP1L3MBTL1GAA | |
| SCHEMBL26733459 | 0.74 | NLRP3 (0.41) | NLRP3LMNAALDH1A1L3MBTL1GAA | |
| SCHEMBL30645975 | 0.74 | NLRP3 (0.39) | NLRP3LMNAALDH1A1L3MBTL1 | |
| SCHEMBL30203027 | 0.74 | NLRP3 (0.44) | NLRP3ALDH1A1 | |
| SCHEMBL26730555 | 0.74 | NLRP3 (0.44) | NLRP3ALDH1A1 | |
| SCHEMBL28781503 | 0.74 | ALDH1A1 (0.45) | NLRP3ALDH1A1L3MBTL1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4301753-A1 | 4-ALKOXY-6-OXO-PYRIDAZINE DERIVATIVES MODULATING NLRP3 | Janssen Pharmaceutica NV (BE) | 2024-01-10 | — | — | EP | disclosed |
| WO-2022184842-A1 | 4-ALKOXY-6-OXO-PYRIDAZINE DERIVATIVES MODULATING NLRP3 | JANSSEN PHARMACEUTICA NV (BE) | 2022-09-09 | — | — | WO | disclosed |