Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 3/20 | 0.44 |
| ▸ | HPGD | P15428 | 3/20 | 0.44 |
| ▸ | GAA | P10253 | 3/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.42 |
| ▸ | GSK3A | P49840 | 1/20 | 0.42 |
| ▸ | GSK3B | P49841 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CNR1 | P21554 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29899373 | 0.85 | ALDH1A1 (0.44) | ALDH1A1KDM4EHTTSMN1; SMN2HSD17B10 | |
| SCHEMBL27185189 | 0.79 | ALDH1A1 (0.39) | ALDH1A1KDM4EHTTSMN1; SMN2HSD17B10 | |
| SCHEMBL29899355 | 0.76 | ALDH1A1 (0.50) | ALDH1A1KDM4EHTTSMN1; SMN2HSD17B10 | |
| Acetic Acid SCHEMBL26982605 | 0.76 | HTT (0.40) | ALDH1A1KDM4EHTTSMN1; SMN2HSD17B10 | |
| SCHEMBL29899375 | 0.76 | KDM4E (0.41) | ALDH1A1KDM4EHTTSMN1; SMN2HSD17B10 | |
| SCHEMBL25746202 | 0.75 | GAA (0.51) | ALDH1A1KDM4EHTTSMN1; SMN2HSD17B10 | |
| SCHEMBL25332258 | 0.73 | KDM4E (0.42) | ALDH1A1KDM4EHTTSMN1; SMN2HSD17B10 | |
| SCHEMBL24077023 | 0.73 | MAPK8 (0.49) | ALDH1A1KDM4EHTTSMN1; SMN2TSHR | |
| SCHEMBL24076898 | 0.73 | GAA (0.49) | ALDH1A1KDM4EHTTGAACYP2C19 | |
| SCHEMBL23792573 | 0.73 | MAPK1 (0.40) | ALDH1A1KDM4EHTTSMN1; SMN2HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240109905-A1 | 4-ALKOXY-6-OXO-PYRIDAZINE DERIVATIVES MODULATING NLRP3 | JANSSEN PHARMACEUTICA NV (BE) | 2024-04-04 | — | — | US | disclosed |
| EP-4301753-A1 | 4-ALKOXY-6-OXO-PYRIDAZINE DERIVATIVES MODULATING NLRP3 | Janssen Pharmaceutica NV (BE) | 2024-01-10 | — | — | EP | disclosed |
| WO-2022184842-A1 | 4-ALKOXY-6-OXO-PYRIDAZINE DERIVATIVES MODULATING NLRP3 | JANSSEN PHARMACEUTICA NV (BE) | 2022-09-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240109905-A1 | 4-ALKOXY-6-OXO-PYRIDAZINE DERIVATIVES MODULATING NLRP3 | NLRP3, NLRP1, PYCARD | ALDH1A1 1823/4885KDM4E 2109/4885HTT 2016/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.