Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | PPARA | Q07869 | 3/20 | 0.41 |
| ▸ | SLC22A12 | Q96S37 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.41 |
| ▸ | HPGD | P15428 | 4/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.41 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.41 |
| ▸ | BLM | P54132 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | EGFR | P00533 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24042028 | 0.83 | PPARA (0.36) | CYP2C9PPARAHPGDMAPTPOLB | |
| SCHEMBL24226063 | 0.80 | ESR1 (0.47) | KDM4ECYP1A2TDP1HPGDCYP3A4 | |
| SCHEMBL29442667 | 0.78 | KDM4E (0.41) | KDM4EL3MBTL1CYP2C9LMNAPPARA | |
| SCHEMBL26166968 | 0.77 | PTGES2 (0.44) | KDM4EL3MBTL1CYP2C9PPARACYP1A2 | |
| SCHEMBL24510621 | 0.76 | KDM4E (0.61) | KDM4EL3MBTL1CYP2C9LMNAPPARA | |
| SCHEMBL18322762 | 0.75 | APP (0.44) | CYP2C9SLC22A12CYP1A2CYP3A4 | |
| SCHEMBL14740848 | 0.74 | CYP1A2 (0.45) | KDM4EL3MBTL1LMNAPPARASLC22A12 | |
| SCHEMBL4457891 | 0.74 | BLM (0.47) | KDM4EL3MBTL1CYP2C9PPARACYP1A2 | |
| SCHEMBL7840765 | 0.74 | PPARA (0.53) | KDM4EL3MBTL1CYP2C9PPARACYP1A2 | |
| SCHEMBL13644181 | 0.74 | KDM4E (0.70) | KDM4ECYP2C9LMNACYP1A2TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3833662-B1 | INHIBITORS OF KEAP1-NRF2 PROTEIN-PROTEIN INTERACTION | JANSSEN PHARMACEUTICA NV (BE) | 2024-01-17 | — | — | EP | disclosed |
| CN-115151538-A | Macrocyclic compounds, process for their preparation and pharmaceutical compositions containing them | 法国施维雅药厂 | 2022-10-04 | — | — | CN | disclosed |