Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARA | Q07869 | 2/20 | 0.36 |
| ▸ | P2RX3 | P56373 | 2/20 | 0.35 |
| ▸ | PTPRB | P23467 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | CNR2 | P34972 | 2/20 | 0.34 |
| ▸ | CNR1 | P21554 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | PTGES2 | Q9H7Z7 | 1/20 | 0.34 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.33 |
| ▸ | PPARG | P37231 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | SHBG | P04278 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29901062 | 0.83 | KDM4E (0.46) | PPARAMEN1KMT2AMAPTHPGD | |
| SCHEMBL11509018 | 0.80 | PTPRB (0.47) | PTPRB | |
| SCHEMBL11648125 | 0.79 | PTGS1 (0.44) | PPARAPTPRBMEN1KMT2AMAPT | |
| SCHEMBL7839814 | 0.79 | HPGD (0.45) | PPARAP2RX3HTTHPGDPOLB | |
| SCHEMBL11530777 | 0.77 | HPGD (0.45) | PTPRBMAPTCNR2CNR1HPGD | |
| SCHEMBL24226063 | 0.77 | ESR1 (0.47) | MEN1KMT2AMAPTCNR2CNR1 | |
| SCHEMBL11646444 | 0.75 | PTPRB (0.44) | PTPRB | |
| SCHEMBL17106362 | 0.75 | MAOB (0.42) | PTPRBMEN1HTTKMT2AMAPT | |
| SCHEMBL14212007 | 0.75 | ALDH1A1 (0.55) | MEN1HTTKMT2AEPHX2POLB | |
| SCHEMBL17106300 | 0.74 | LMNA (0.46) | MEN1HTTKMT2AHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3555082-B1 | ETHER LINKED TRIAZOLES AS NRF2 REGULATORS | GLAXOSMITHKLINE IP DEV LTD (GB) | 2022-01-26 | — | — | EP | disclosed |
| EP-3555088-B1 | BISARYL AMIDES AS NRF2 REGULATORS | GLAXOSMITHKLINE IP DEV LTD (GB) | 2021-11-24 | — | — | EP | disclosed |