Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 1/20 | 0.43 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.43 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.43 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.43 |
| ▸ | SMYD3 | Q9H7B4 | 3/20 | 0.42 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
| ▸ | JAK2 | O60674 | 1/20 | 0.41 |
| ▸ | JAK1 | P23458 | 1/20 | 0.41 |
| ▸ | TYK2 | P29597 | 1/20 | 0.41 |
| ▸ | JAK3 | P52333 | 1/20 | 0.41 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.40 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.40 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.39 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.39 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.39 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.39 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.39 |
| ▸ | PIM1 | P11309 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25690440 | 0.74 | CHRNB2 (0.45) | CHRNB2CHRNB4CHRNA3CHRNA4SMYD3 | |
| SCHEMBL25053099 | 0.74 | HSD11B1 (0.52) | CHRNB2CHRNB4CHRNA3CHRNA4SMYD3 | |
| SCHEMBL24151463 | 0.74 | GRM5 (0.53) | CHRNB2CHRNB4CHRNA3CHRNA4HSD11B1 | |
| SCHEMBL30380486 | 0.73 | HSD11B1 (0.51) | CHRNB2CHRNB4CHRNA3CHRNA4SMYD3 | |
| SCHEMBL24148772 | 0.73 | HSD11B1 (0.51) | CHRNB2CHRNB4CHRNA3CHRNA4SMYD3 | |
| SCHEMBL13267799 | 0.73 | PRKAA2 (0.53) | CHRNB2CHRNB4CHRNA3CHRNA4HSD11B1 | |
| SCHEMBL3002690 | 0.72 | PIM1 (0.39) | PIM1ALDH1A1 | |
| SCHEMBL3313500 | 0.72 | POLB (0.39) | JAK3MAPK1ALDH1A1DYRK1A | |
| SCHEMBL10263897 | 0.72 | SMYD3 (0.45) | CHRNB2CHRNB4CHRNA3CHRNA4SMYD3 | |
| SCHEMBL30380003 | 0.72 | CD38 (0.46) | CHRNB2CHRNB4CHRNA3CHRNA4SMYD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100190773-A1 | Anti-Cytokine Heterocyclic Compounds | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2010-07-29 | — | — | US | claimed |
| US-20060276496-A1 | Anti-Cytokine Heterocyclic Compounds | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 2006-12-07 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060276496-A1 | Anti-Cytokine Heterocyclic Compounds | MAPKAPK2, MAP4K2, MAP3K2 | CHRNB2 2808/4885CHRNB4 3807/4885CHRNA3 4181/4885 |
| US-20100190773-A1 | Anti-Cytokine Heterocyclic Compounds | MAPKAPK2, MAP4K2, MAP3K2 | CHRNB2 2808/4885CHRNB4 3807/4885CHRNA3 4181/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.