Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | SYK | P43405 | 1/20 | 0.52 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.49 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.49 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.49 |
| ▸ | KLK5 | Q9Y337 | 3/20 | 0.48 |
| ▸ | BCHE | P06276 | 2/20 | 0.48 |
| ▸ | ACHE | P22303 | 2/20 | 0.48 |
| ▸ | KLK7 | P49862 | 2/20 | 0.48 |
| ▸ | ESR1 | P03372 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | IDO1 | P14902 | 1/20 | 0.46 |
| ▸ | CTSS | P25774 | 2/20 | 0.45 |
| ▸ | KYNU | Q16719 | 1/20 | 0.45 |
| ▸ | PPARA | Q07869 | 1/20 | 0.45 |
| ▸ | CAPN1 | P07384 | 1/20 | 0.44 |
| ▸ | CAPN2 | P17655 | 1/20 | 0.44 |
| ▸ | CTSL | P07711 | 1/20 | 0.44 |
| ▸ | CTSB | P07858 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30638287 | 1.00 | LMNA (0.52) | LMNASMN1; SMN2SYKSIRT2SIRT1 | |
| SCHEMBL22090527 | 0.94 | SIRT2 (0.51) | LMNASMN1; SMN2SYKSIRT2SIRT1 | |
| SCHEMBL15382100 | 0.92 | LMNA (0.57) | LMNASMN1; SMN2SIRT2SIRT1SIRT3 | |
| SCHEMBL29467688 | 0.91 | LMNA (0.49) | LMNASMN1; SMN2SYKSIRT2SIRT1 | |
| SCHEMBL18211259 | 0.90 | SIRT2 (0.53) | LMNASMN1; SMN2SYKSIRT2SIRT1 | |
| SCHEMBL21171608 | 0.90 | SIRT2 (0.53) | LMNASMN1; SMN2SYKSIRT2SIRT1 | |
| SCHEMBL18211265 | 0.90 | SIRT2 (0.53) | LMNASMN1; SMN2SYKSIRT2SIRT1 | |
| SCHEMBL25132765 | 0.90 | SYK (0.49) | LMNASMN1; SMN2SYKSIRT2KLK5 | |
| SCHEMBL29902259 | 0.88 | LMNA (0.47) | LMNASMN1; SMN2SYKSIRT2SIRT1 | |
| SCHEMBL29902227 | 0.88 | LMNA (0.47) | LMNASMN1; SMN2SYKSIRT2SIRT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200031862-A1 | LIGAND-MODIFIED DOUBLE-STRANDED NUCLEIC ACIDS | DICERNA PHARMACEUTICALS, INC. | 2020-01-30 | — | — | US | disclosed |
| US-20170305956-A1 | Ligand-Modified Double-Stranded Nucleic Acids | NOVO NORDISK A/S (DK) | 2017-10-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200031862-A1 | LIGAND-MODIFIED DOUBLE-STRANDED NUCLEIC ACIDS | ADAR, NCL, SSU72 | LMNA 528/4885SMN1; SMN2 1237/4885SYK 3726/4885 |
| US-20170305956-A1 | Ligand-Modified Double-Stranded Nucleic Acids | ADAR, NCL, SSU72 | LMNA 528/4885SMN1; SMN2 1237/4885SYK 3726/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.