Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPRB | P23467 | 5/20 | 0.55 |
| ▸ | PTPN2 | P17706 | 5/20 | 0.49 |
| ▸ | PTPN1 | P18031 | 5/20 | 0.49 |
| ▸ | PTPN11 | Q06124 | 5/20 | 0.49 |
| ▸ | PTPN4 | P29074 | 1/20 | 0.49 |
| ▸ | PTPN9 | P43378 | 1/20 | 0.49 |
| ▸ | ING2 | Q9H160 | 2/20 | 0.45 |
| ▸ | DUSP5 | Q16690 | 1/20 | 0.42 |
| ▸ | DUSP6 | Q16828 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.37 |
| ▸ | CA4 | P22748 | 1/20 | 0.37 |
| ▸ | CA5A | P35218 | 1/20 | 0.37 |
| ▸ | CD69 | Q07108 | 1/20 | 0.36 |
| ▸ | FBP1 | P09467 | 2/20 | 0.35 |
| ▸ | GSTA1 | P08263 | 5/20 | 0.35 |
| ▸ | GSTP1 | P09211 | 5/20 | 0.35 |
| ▸ | PTPRC | P08575 | 4/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2984001 | 1.00 | PTPRB (0.55) | PTPRBPTPN2PTPN1PTPN11PTPN4 | |
| SCHEMBL20379784 | 0.73 | CA2 (0.53) | CA2CA4CA5AFBP1 | |
| SCHEMBL14252038 | 0.72 | CA2 (0.42) | CA2CA4CA5AKDM4E | |
| SCHEMBL14848390 | 0.71 | PTPRB (0.58) | PTPRBPTPN2PTPN1PTPN11PTPN4 | |
| SCHEMBL2990563 | 0.70 | PTPRB (0.44) | PTPRBPTPN2PTPN1PTPN11PTPN4 | |
| SCHEMBL6395721 | 0.69 | BACE1 (0.47) | CA2CA4CA5A | |
| SCHEMBL4148579 | 0.68 | CA2 (0.39) | CA2CA4CA5A | |
| SCHEMBL13541165 | 0.68 | CA2 (0.48) | CA2CA4CA5AKDM4ECYP1A2 | |
| SCHEMBL859577 | 0.65 | CA2 (0.36) | CA2CA4CA5AKDM4E | |
| SCHEMBL11704478 | 0.64 | CA2 (0.54) | CA2CYP1A2ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8252954-B2 | Processes for the preparation of calixarene derivatives | THE CURATORS OF THE UNIVERSITY OF MISSOURI (US) | 2012-08-28 | — | — | US | disclosed |
| US-20100185022-A1 | PROCESSES FOR THE PREPARATION OF CALIXARENE DERIVATIVES | THE UNIVERSITY OF WESTERN AUSTRALIA (AU) | 2010-07-22 | — | — | US | disclosed |
| WO-2008148168-A1 | PROCESSES FOR THE PREPARATION OF CALIXARENE DERIVATIVES | THE UNIVERSITY OF WESTERN AUSTRALIA (AU) | 2008-12-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100185022-A1 | PROCESSES FOR THE PREPARATION OF CALIXARENE DERIVATIVES | CALD1, CANX, CALU | PTPRB 250/4885PTPN2 930/4885PTPN1 791/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.