Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKMYT1 | Q99640 | 2/20 | 0.55 |
| ▸ | INSR | P06213 | 1/20 | 0.55 |
| ▸ | IGF1R | P08069 | 1/20 | 0.55 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.55 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.55 |
| ▸ | MAPK9 | P45984 | 4/20 | 0.54 |
| ▸ | MAPK10 | P53779 | 4/20 | 0.54 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.54 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.54 |
| ▸ | EGFR | P00533 | 4/20 | 0.54 |
| ▸ | ALK | Q9UM73 | 3/20 | 0.54 |
| ▸ | ROS1 | P08922 | 1/20 | 0.54 |
| ▸ | CCNK | O75909 | 1/20 | 0.54 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.54 |
| ▸ | CDK2 | P24941 | 1/20 | 0.54 |
| ▸ | CCND3 | P30281 | 1/20 | 0.54 |
| ▸ | CDK9 | P50750 | 1/20 | 0.54 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.54 |
| ▸ | MAP3K7 | O43318 | 2/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26906640 | 1.00 | PKMYT1 (0.55) | PKMYT1INSRIGF1RPTK2PTK2B | |
| SCHEMBL19831454 | 0.79 | PTK2 (0.64) | PKMYT1INSRIGF1RPTK2PTK2B | |
| SCHEMBL26906721 | 0.77 | CDK9 (0.59) | PKMYT1INSRIGF1RPTK2PTK2B | |
| SCHEMBL29904658 | 0.77 | CDK9 (0.59) | PKMYT1INSRIGF1RPTK2PTK2B | |
| SCHEMBL29904686 | 0.76 | CCNK (0.60) | PKMYT1INSRIGF1RPTK2PTK2B | |
| SCHEMBL29114906 | 0.75 | — | — | |
| SCHEMBL50482 | 0.74 | MAPT (0.69) | RAB9A | |
| SCHEMBL28860458 | 0.73 | EGFR (0.54) | PKMYT1INSRIGF1RPTK2PTK2B | |
| SCHEMBL13321204 | 0.72 | CCNK (0.60) | PKMYT1INSRIGF1RPTK2PTK2B | |
| SCHEMBL28980964 | 0.72 | MAP3K7 (0.72) | IGF1RPTK2MAPK9MAPK8SLC2A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022211573-A1 | PYRIMIDINE DERIVATIVE HAVING PROTEIN KINASE INHIBITORY ACTIVITY, AND THERAPEUTIC PHARMACEUTICAL COMPOSITION COMPRISING SAME | 주식회사 테라펙스 | 2022-10-06 | — | — | WO | claimed |
| CN-117120424-A | Pyrimidine derivatives having protein kinase inhibitory activity and therapeutic combinations comprising the same | 泰拉佩克斯有限公司 | 2023-11-24 | — | — | CN | disclosed |
| WO-2022211573-A1 | PYRIMIDINE DERIVATIVE HAVING PROTEIN KINASE INHIBITORY ACTIVITY, AND THERAPEUTIC PHARMACEUTICAL COMPOSITION COMPRISING SAME | 주식회사 테라펙스 | 2022-10-06 | — | — | WO | disclosed |