Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.34 |
| ▸ | MAOB | P27338 | 3/20 | 0.33 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.33 |
| ▸ | MAOA | P21397 | 1/20 | 0.33 |
| ▸ | ACHE | P22303 | 1/20 | 0.33 |
| ▸ | VNN1 | O95497 | 1/20 | 0.33 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.33 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.33 |
| ▸ | TCF7 | P36402 | 1/20 | 0.33 |
| ▸ | CDC7 | O00311 | 1/20 | 0.33 |
| ▸ | TRPM5 | Q9NZQ8 | 1/20 | 0.33 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.33 |
| ▸ | AURKA | O14965 | 1/20 | 0.33 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.33 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.33 |
| ▸ | GSK3A | P49840 | 1/20 | 0.33 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.33 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21172 | 0.88 | TRPA1 (0.42) | CA1CA2TRPA1MAOBMAOA | |
| SCHEMBL29722623 | 0.88 | TRPA1 (0.42) | CA1CA2TRPA1MAOBMAOA | |
| SCHEMBL29953317 | 0.75 | NOTUM (0.44) | CA1CA2VNN1PDE1CENPP2 | |
| SCHEMBL876657 | 0.75 | NOTUM (0.44) | CA1CA2VNN1PDE1CENPP2 | |
| SCHEMBL30855622 | 0.75 | EGFR (0.38) | TRPA1MAOBTGFBR1MAOAACHE | |
| SCHEMBL26027127 | 0.74 | ACLY (0.41) | CA1CA2CHEK1AURKADAPK3 | |
| SCHEMBL31089867 | 0.74 | ACLY (0.41) | CA1CA2CHEK1AURKADAPK3 | |
| SCHEMBL4251433 | 0.74 | HTR2A (0.39) | CA1CA2TGFBR1 | |
| SCHEMBL24858407 | 0.71 | CA1 (0.38) | CA1CA2ENPP2 | |
| SCHEMBL31097199 | 0.71 | CTNNB1 (0.44) | TRPA1TGFBR1VNN1CTNNB1TCF7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4493558-A1 | TRICYCLIC UREA COMPOUNDS AS JAK2 V617F INHIBITORS | Incyte Corporation (US) | 2025-01-22 | — | — | EP | disclosed |
| CN-119173514-A | Tricyclic urea compounds as JAK 2V 617F inhibitors | 因赛特公司 | 2024-12-20 | — | — | CN | disclosed |
| WO-2024086273-A1 | TRICYCLIC UREA COMPOUNDS AS JAK2 V617F INHIBITORS | INCYTE CORPORATION (US) | 2024-04-25 | — | — | WO | disclosed |
| EP-4298099-A1 | SPIROCYCLIC LACTAMS AS JAK2 V617F INHIBITORS | Incyte Corporation (US) | 2024-01-03 | — | — | EP | disclosed |
| WO-2023178285-A1 | TRICYCLIC UREA COMPOUNDS AS JAK2 V617F INHIBITORS | INCYTE CORPORATION (US) | 2023-09-21 | — | — | WO | disclosed |
| WO-2022182839-A1 | SPIROCYCLIC LACTAMS AS JAK2 V617F INHIBITORS | INCYTE CORPORATION (US) | 2022-09-01 | — | — | WO | disclosed |