Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AXL | P30530 | 1/20 | 0.50 |
| ▸ | PGK1 | P00558 | 3/20 | 0.41 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.40 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.39 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.39 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | MAOB | P27338 | 3/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | MAOA | P21397 | 1/20 | 0.37 |
| ▸ | NOS1 | P29475 | 2/20 | 0.37 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.37 |
| ▸ | BRD4 | O60885 | 1/20 | 0.36 |
| ▸ | AURKA | O14965 | 1/20 | 0.36 |
| ▸ | RET | P07949 | 2/20 | 0.35 |
| ▸ | KDR | P35968 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23210862 | 1.00 | AXL (0.50) | AXLPGK1TLR8MKNK1TRPA1 | |
| SCHEMBL26632171 | 0.78 | NOS1 (0.41) | TRPA1KDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL31133339 | 0.76 | NOS1 (0.42) | TRPA1TRPM8KDM4EALDH1A1MAOB | |
| SCHEMBL3560175 | 0.72 | AXL (0.73) | AXLTLR8MKNK1TRPA1TRPM8 | |
| SCHEMBL29109556 | 0.70 | AXL (0.60) | AXLTLR8MKNK1TRPA1TRPM8 | |
| SCHEMBL33527188 | 0.70 | KHK (0.42) | TRPA1ALDH1A1SMN1; SMN2NOS1DYRK1A | |
| SCHEMBL29509917 | 0.69 | KMO (0.46) | TLR8TRPA1KDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL25341600 | 0.69 | KMO (0.46) | TLR8TRPA1KDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL20617830 | 0.68 | AXL (0.67) | AXLTLR8MKNK1TRPA1TRPM8 | |
| SCHEMBL31599741 | 0.68 | TRPA1 (0.40) | TRPA1KDM4EALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115835908-A | Bicyclic heterocycles as FGFR inhibitors | 因赛特公司 | 2023-03-21 | — | — | CN | disclosed |
| EP-4045151-A1 | BICYCLIC HETEROCYCLES AS FGFR INHIBITORS | Incyte Corporation (US) | 2022-08-24 | — | — | EP | disclosed |