Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TTK | P33981 | 11/20 | 0.37 |
| ▸ | RET | P07949 | 3/20 | 0.35 |
| ▸ | PGK1 | P00558 | 1/20 | 0.34 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.34 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.34 |
| ▸ | CDK2 | P24941 | 2/20 | 0.34 |
| ▸ | AURKA | O14965 | 1/20 | 0.34 |
| ▸ | GSK3B | P49841 | 1/20 | 0.34 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.34 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.33 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.33 |
| ▸ | ACVR2A | P27037 | 1/20 | 0.33 |
| ▸ | TGFBR2 | P37173 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23210931 | 0.95 | TTK (0.40) | TTKRETPGK1GPR119CCNA2 | |
| SCHEMBL29907124 | 0.95 | TTK (0.40) | TTKRETPGK1GPR119CCNA2 | |
| SCHEMBL23236535 | 0.86 | SUV39H2 (0.35) | — | |
| SCHEMBL26632174 | 0.83 | TTK (0.41) | TTKRETGPR119CCNA2CDK2 | |
| SCHEMBL23210978 | 0.82 | PGK1 (0.40) | TTKPGK1CCNA2CDK2LRRK2 | |
| SCHEMBL23263988 | 0.79 | TTK (0.42) | TTKRETCCNA2CDK2AURKA | |
| SCHEMBL23210988 | 0.74 | RET (0.37) | TTKRETGPR119ACVR2ATGFBR2 | |
| SCHEMBL29907198 | 0.74 | RET (0.37) | TTKRETGPR119ACVR2ATGFBR2 | |
| SCHEMBL26632173 | 0.73 | FAAH (0.34) | DYRK1A | |
| SCHEMBL20804310 | 0.73 | RET (0.42) | TTKRETGPR119GSK3BDYRK1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4045151-A1 | BICYCLIC HETEROCYCLES AS FGFR INHIBITORS | Incyte Corporation (US) | 2022-08-24 | — | — | EP | disclosed |