Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 2/20 | 0.52 |
| ▸ | JAK1 | P23458 | 2/20 | 0.52 |
| ▸ | TYK2 | P29597 | 2/20 | 0.52 |
| ▸ | JAK3 | P52333 | 1/20 | 0.52 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.50 |
| ▸ | HPGDS | O60760 | 2/20 | 0.48 |
| ▸ | PARP1 | P09874 | 5/20 | 0.48 |
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | THRB | P10828 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19297242 | 1.00 | JAK2 (0.52) | JAK2JAK1TYK2JAK3PDE10A | |
| SCHEMBL22608960 | 0.94 | HPGDS (0.50) | JAK2JAK1TYK2JAK3PDE10A | |
| SCHEMBL2347633 | 0.83 | PDE10A (0.54) | JAK2JAK1TYK2JAK3PDE10A | |
| SCHEMBL29844615 | 0.82 | JAK2 (0.52) | JAK2JAK1TYK2JAK3GPR119 | |
| SCHEMBL29337387 | 0.81 | DRD2 (0.51) | PARP1GPR119MAPT | |
| SCHEMBL23442909 | 0.80 | GPR119 (0.51) | JAK2JAK1TYK2JAK3PDE10A | |
| SCHEMBL30368710 | 0.80 | GPR119 (0.51) | JAK2JAK1TYK2JAK3PDE10A | |
| SCHEMBL19284734 | 0.80 | GPR119 (0.54) | JAK2JAK3PDE10AHPGDSGPR119 | |
| SCHEMBL14143336 | 0.80 | JAK1 (0.57) | JAK2JAK1TYK2JAK3PDE10A | |
| SCHEMBL19297153 | 0.78 | GPR119 (0.46) | JAK2JAK1TYK2JAK3PDE10A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4326719-A1 | PYRIDO[3,2-D]PYRIMIDINE COMPOUNDS USES THEREOF FOR TREATING A PROLIFERATIVE DISEASE | Université de Montréal (CA) | 2024-02-28 | — | — | EP | disclosed |
| CN-117177973-A | Pyrido [3,2-D ] pyrimidine compounds and their use for the treatment of proliferative disorders | 蒙特利尔大学 | 2023-12-05 | — | — | CN | disclosed |
| WO-2022221939-A1 | PYRIDO[3,2-D]PYRIMIDINE COMPOUNDS USES THEREOF FOR TREATING A PROLIFERATIVE DISEASE | UNIVERSITE DE MONTREAL (CA) | 2022-10-27 | — | — | WO | disclosed |