Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGES2 | Q9H7Z7 | 8/20 | 0.56 |
| ▸ | ACLY | P53396 | 4/20 | 0.50 |
| ▸ | CCR4 | P51679 | 7/20 | 0.47 |
| ▸ | CCR2 | P41597 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27139881 | 1.00 | PTGES2 (0.56) | PTGES2ACLYCCR4CCR2 | |
| SCHEMBL27146412 | 0.87 | PTGES2 (0.59) | PTGES2ACLYCCR2 | |
| SCHEMBL29907264 | 0.87 | PTGES2 (0.59) | PTGES2ACLYCCR2 | |
| SCHEMBL29907260 | 0.78 | PTGES2 (0.67) | PTGES2ACLYCCR4CCR2 | |
| SCHEMBL27143523 | 0.78 | PTGES2 (0.67) | PTGES2ACLYCCR4CCR2 | |
| SCHEMBL3985762 | 0.76 | TSHR (0.55) | PTGES2ACLYCCR2 | |
| SCHEMBL27152893 | 0.74 | PTGES2 (0.57) | PTGES2ACLYCCR4CCR2 | |
| SCHEMBL17599356 | 0.73 | ACLY (0.51) | PTGES2ACLY | |
| SCHEMBL7852262 | 0.72 | PTGES2 (0.68) | PTGES2ACLYCCR4 | |
| SCHEMBL30897292 | 0.72 | PTGES2 (0.61) | PTGES2ACLYCCR4CCR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4326723-A1 | PYRIMIDO[5,4,D]PYRIMIDINE COMPOUNDS, COMPOSITIONS COMPRISING THEM AND USES THEREOF | Université de Montréal (CA) | 2024-02-28 | — | — | EP | disclosed |
| EP-4326719-A1 | PYRIDO[3,2-D]PYRIMIDINE COMPOUNDS USES THEREOF FOR TREATING A PROLIFERATIVE DISEASE | Université de Montréal (CA) | 2024-02-28 | — | — | EP | disclosed |
| CN-117177973-A | Pyrido [3,2-D ] pyrimidine compounds and their use for the treatment of proliferative disorders | 蒙特利尔大学 | 2023-12-05 | — | — | CN | disclosed |
| WO-2022221939-A1 | PYRIDO[3,2-D]PYRIMIDINE COMPOUNDS USES THEREOF FOR TREATING A PROLIFERATIVE DISEASE | UNIVERSITE DE MONTREAL (CA) | 2022-10-27 | — | — | WO | disclosed |
| WO-2022221940-A1 | PYRIMIDO[5,4,D]PYRIMIDINE COMPOUNDS, COMPOSITIONS COMPRISING THEM AND USES THEREOF | UNIVERSITE DE MONTREAL (CA) | 2022-10-27 | — | — | WO | disclosed |