Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSIP1 | O75475 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | KAT6A | Q92794 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.33 |
| ▸ | IKBKB | O14920 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27141810 | 1.00 | PSIP1 (0.37) | PSIP1KDM4ELMNAKAT6AKMT2A | |
| SCHEMBL4119928 | 0.85 | PSIP1 (0.39) | PSIP1KDM4ELMNAKAT6AKMT2A | |
| SCHEMBL27985611 | 0.83 | KMT2A (0.39) | PSIP1LMNAKAT6AKMT2ATDP1 | |
| SCHEMBL18209561 | 0.81 | PTGES2 (0.44) | PSIP1KMT2ATDP1RXFP1 | |
| SCHEMBL27143889 | 0.79 | AKR1B1 (0.38) | KDM4ELMNAKMT2ATDP1TAAR1 | |
| SCHEMBL31566482 | 0.76 | TRPV4 (0.39) | SMN1; SMN2TRPV4 | |
| SCHEMBL91337 | 0.75 | KDM4E (0.45) | PSIP1KDM4EKMT2ATAAR1GAA | |
| SCHEMBL1199464 | 0.75 | SLC40A1 (0.43) | KAT6AKMT2AGAASMN1; SMN2TRPV4 | |
| SCHEMBL1515862 | 0.74 | PTGES2 (0.46) | KAT6ATDP1AKR1B1HSD17B10TRPV4 | |
| SCHEMBL29543283 | 0.74 | PTGES2 (0.46) | KAT6ATDP1AKR1B1HSD17B10TRPV4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4326719-A1 | PYRIDO[3,2-D]PYRIMIDINE COMPOUNDS USES THEREOF FOR TREATING A PROLIFERATIVE DISEASE | Université de Montréal (CA) | 2024-02-28 | — | — | EP | disclosed |
| EP-4326723-A1 | PYRIMIDO[5,4,D]PYRIMIDINE COMPOUNDS, COMPOSITIONS COMPRISING THEM AND USES THEREOF | Université de Montréal (CA) | 2024-02-28 | — | — | EP | disclosed |
| WO-2022221939-A1 | PYRIDO[3,2-D]PYRIMIDINE COMPOUNDS USES THEREOF FOR TREATING A PROLIFERATIVE DISEASE | UNIVERSITE DE MONTREAL (CA) | 2022-10-27 | — | — | WO | disclosed |
| WO-2022221940-A1 | PYRIMIDO[5,4,D]PYRIMIDINE COMPOUNDS, COMPOSITIONS COMPRISING THEM AND USES THEREOF | UNIVERSITE DE MONTREAL (CA) | 2022-10-27 | — | — | WO | disclosed |