Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 3/20 | 0.50 |
| ▸ | ATM | Q13315 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.44 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.44 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.43 |
| ▸ | CTSS | P25774 | 1/20 | 0.43 |
| ▸ | SMG1 | Q96Q15 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | NSD2 | O96028 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2814727 | 1.00 | LRRK2 (0.52) | LRRK2HTTATML3MBTL1GAA | |
| SCHEMBL21730194 | 0.84 | CTSS (0.46) | L3MBTL1ALDH1A1KDM4EHPGDTSHR | |
| SCHEMBL21730383 | 0.84 | CTSS (0.46) | ALDH1A1KDM4EHPGDCTSS | |
| SCHEMBL29907703 | 0.84 | CTSS (0.46) | L3MBTL1ALDH1A1KDM4EHPGDTSHR | |
| SCHEMBL2949577 | 0.83 | CTSS (0.45) | L3MBTL1HSD17B10ALDH1A1KDM4EHPGD | |
| SCHEMBL2962315 | 0.82 | SMN1; SMN2 (0.48) | HTTL3MBTL1GAAHSD17B10ALDH1A1 | |
| SCHEMBL6843345 | 0.82 | GAA (0.59) | HTTGAAHSD17B10ALDH1A1KDM4E | |
| SCHEMBL27920871 | 0.81 | CTSS (0.44) | LRRK2HTTATML3MBTL1ALDH1A1 | |
| SCHEMBL21268766 | 0.80 | ALDH1A1 (0.58) | HTTATMGAAHSD17B10ALDH1A1 | |
| SCHEMBL30893584 | 0.80 | ALDH1A1 (0.58) | HTTATMGAAHSD17B10ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115181092-B | Pyrazine compounds and uses thereof | 迪哲(江苏)医药股份有限公司 | 2024-05-03 | — | — | CN | disclosed |
| CN-115181092-A | Pyrazine compounds and uses thereof | 迪哲(江苏)医药股份有限公司 | 2022-10-14 | — | — | CN | disclosed |
| CN-112279837-B | Pyrazine compounds and uses thereof | 迪哲(江苏)医药股份有限公司 | 2022-08-09 | — | — | CN | disclosed |