Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 4/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.44 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.43 |
| ▸ | NCF1 | P14598 | 3/20 | 0.41 |
| ▸ | ITGB3 | P05106 | 4/20 | 0.37 |
| ▸ | ITGAV | P06756 | 4/20 | 0.37 |
| ▸ | AOC1 | P19801 | 1/20 | 0.35 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.35 |
| ▸ | ITGB6 | P18564 | 1/20 | 0.35 |
| ▸ | ITGB1 | P05556 | 3/20 | 0.34 |
| ▸ | ITGA5 | P08648 | 3/20 | 0.34 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.34 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.34 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.34 |
| ▸ | ITGB5 | P18084 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.33 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5631959 | 1.00 | APP (0.47) | APPKCNH2SCN5APDE10ANCF1 | |
| SCHEMBL1815740 | 0.84 | APP (0.53) | APPKCNH2SCN5APDE10ANCF1 | |
| SCHEMBL19514887 | 0.81 | APP (0.55) | APPKCNH2SCN5APDE10ANCF1 | |
| SCHEMBL30336032 | 0.81 | APP (0.55) | APPKCNH2SCN5APDE10ANCF1 | |
| SCHEMBL6602310 | 0.81 | KCNH2 (0.55) | APPKCNH2SCN5APDE10ANCF1 | |
| SCHEMBL7796045 | 0.80 | CACNA1C (0.49) | APPKCNH2SCN5ANCF1AOC1 | |
| SCHEMBL18160808 | 0.80 | NCF1 (0.36) | APPKCNH2SCN5APDE10ANCF1 | |
| SCHEMBL15539333 | 0.79 | APP (0.47) | APPKCNH2SCN5APDE10ANCF1 | |
| SCHEMBL21094552 | 0.79 | ADRB2 (0.35) | APPPIK3CDPIK3CAPIK3CGNR3C2 | |
| SCHEMBL20971411 | 0.79 | APP (0.47) | APPKCNH2SCN5APDE10ANCF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115181092-B | Pyrazine compounds and uses thereof | 迪哲(江苏)医药股份有限公司 | 2024-05-03 | — | — | CN | disclosed |
| CN-115181092-A | Pyrazine compounds and uses thereof | 迪哲(江苏)医药股份有限公司 | 2022-10-14 | — | — | CN | disclosed |
| CN-112279837-B | Pyrazine compounds and uses thereof | 迪哲(江苏)医药股份有限公司 | 2022-08-09 | — | — | CN | disclosed |