Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S100A4 | P26447 | 2/20 | 0.44 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | HTR2B | P41595 | 1/20 | 0.41 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.38 |
| ▸ | AR | P10275 | 2/20 | 0.38 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.38 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.38 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MAOB | P27338 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | GLS | O94925 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | BRD4 | O60885 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18988275 | 1.00 | S100A4 (0.44) | S100A4P2RX7MAPTTP53LMNA | |
| Trifluoroacetic Acid SCHEMBL23150416 | 0.86 | P2RX7 (0.44) | S100A4P2RX7MAPTTP53LMNA | |
| SCHEMBL2404815 | 0.81 | SLC6A2 (0.44) | S100A4P2RX7HTR2BADORA3AR | |
| SCHEMBL18988846 | 0.75 | P2RX7 (0.45) | S100A4P2RX7MAPTADORA3AR | |
| SCHEMBL8695216 | 0.75 | P2RX7 (0.51) | P2RX7MAPTLMNAADORA3AR | |
| SCHEMBL6863573 | 0.75 | BCHE (0.53) | S100A4P2RX7TP53LMNACYP1A2 | |
| SCHEMBL7127619 | 0.75 | P2RX7 (0.40) | S100A4P2RX7ADORA3ARHSD11B1 | |
| SCHEMBL20252628 | 0.75 | P2RX7 (0.51) | P2RX7MAPTLMNAADORA3AR | |
| Hydrochloric Acid SCHEMBL7120126 | 0.74 | P2RX7 (0.39) | S100A4P2RX7ADORA3ARHSD11B1 | |
| SCHEMBL11869810 | 0.74 | KDM1A (0.42) | P2RX7MAPTLMNAKDM4EHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11471441-B2 | Compounds useful as kinase inhibitors | LOXO ONCOLOGY INC. (US) | 2022-10-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11471441-B2 | Compounds useful as kinase inhibitors | BTK, ABL1, LCK | S100A4 4490/4885P2RX7 2246/4885MAPT 3956/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.